ID C3Z7S9_BRAFL Unreviewed; 339 AA.
AC C3Z7S9;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=TNF family profile domain-containing protein {ECO:0000259|Pfam:PF00229};
GN ORFNames=BRAFLDRAFT_69253 {ECO:0000313|EMBL:EEN51434.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN51434.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN51434.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN51434.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG666591; EEN51434.1; -; Genomic_DNA.
DR RefSeq; XP_002595422.1; XM_002595376.1.
DR AlphaFoldDB; C3Z7S9; -.
DR InParanoid; C3Z7S9; -.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR PANTHER; PTHR15151:SF26; TNF_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 229..328
FT /note="TNF family profile"
FT /evidence="ECO:0000259|Pfam:PF00229"
SQ SEQUENCE 339 AA; 37316 MW; C021B154F6FE0E8F CRC64;
MTCMTAVCER GEKTCSGAHG TAISRWQLAC VCLSVVAITL SLFTLFWVHK IVQDLEQNCG
CEVRERADEG HFASVASISG SSGLQDVGTR DIEPDTDNVK FFIYSCALQT TQLVRRDAGD
EEEEAQSRIK RAKGNRDKRK FCKKVTNCMK NDTDTYGFFD ALTVIGELRQ NVTQEVQKLL
TRSYIHRVRP DDVEMLGTFK DVQGGETVLS VKVAPGDIAE RSGDEGMTTI QGGGLYLVYG
QLTYNRQMKG KRLSYNGPMI VISDKNGNSD RFLSCLQPYP VNTTGIPTSC FTAGVVPLQQ
EMRINLTASV MGEIYIDDDK TFLGAVKLAE LPPEPSDGG
//
