ID   C3ZC06_BRAFL            Unreviewed;      1543 AA.
AC   C3ZC06;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   13-SEP-2023, entry version 63.
DE   RecName: Full=Death domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BRAFLDRAFT_98235 {ECO:0000313|EMBL:EEN49947.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN49947.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN49947.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN49947.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; GG666604; EEN49947.1; -; Genomic_DNA.
DR   RefSeq; XP_002593936.1; XM_002593890.1.
DR   eggNOG; ENOG502QTJW; Eukaryota.
DR   InParanoid; C3ZC06; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR46844; SLR5058 PROTEIN; 1.
DR   PANTHER; PTHR46844:SF1; SLR5058 PROTEIN; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF05729; NACHT; 2.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50837; NACHT; 2.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
FT   DOMAIN          95..164
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   DOMAIN          250..367
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          650..780
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   DOMAIN          894..1011
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   1543 AA;  175669 MW;  5405158076E6B54B CRC64;
     MCCEGYFRES MLWQLRAKSQ IYFVRSRGVH DVRSLASNVV LKGWVLNAPP SPPLFQKVLC
     QRLRRKVQLG KTNSHVKNND VQEYFDDVIG EVSHKWDDLA RKLGFKENRI KGIRSSERDN
     DHRCREVLNR WRNREGRRAT LQVLQQALID IGETHTAENL NGTAAPPSGS GGPSSVEDVI
     NTIKDLYATE YAKVRPLPWC EDPSLPLGEV YTNLRHQRKD RKGRFEETGS IVSLADIYNR
     SKTKSTPDVR RIRVEGDPGI GKSCSCQKLA HDWSSGKLDI FMAVFFLEMR HMSGKVKDAI
     FEQLLPDDTN MTPDQLWSYI QENQDDVLFI LDGLDELSQT AREVTDVVVL IQGKILRNCH
     VLVTSRPYHC VKDLEKCHEF YKIVGYSEDD SVQFIEKYFT ETPESARKVV EQLKRNQNLS
     RLVVNPLNNV LICIVWEDNE GKLPSSLAEL YQMMVYSVAK RYCAKKNIPS EGAKIPSNIE
     EALRCLGKLS WEGLEQDQLQ FTINDITEKY GHNADDMLAI GLLTRDNSFS RIKRTCFCSF
     LHKTFQEYMA AWYISDMVKK ESKRDESKEC LRSLFGMTEA ASSNVDMGLM AINRDRYKEI
     QNMVLSILGD SSGLLFEMFA EELSKDGCKG EGKDLLSFIC IAFLGRACGA EPRVFVIHAG
     EDKDSFVRPL VGNLQQQGLA EKDIFFDDVS IKPGDVIRDR IMSTLSSESL EVAVIAVSSS
     FLNKSYWPRL EYETCLKNNK HIFPIWVDAN EDKFKAFSES VGRYSPTLKQ MSARRVQRDD
     VTNELPNIAA EIAQRLSTLS HGHGVARTAG PLCTVDDVIN SLKDLYVTEY ASVRPLPWCE
     DLNLPLGEVY TNLRHQRRGN WGYFHDTCTI VSLEDIFKTN QAKAKNVHTR GAVRRIRVEG
     DPGIGKSCSC QKLAHDWSTG KLDIFKTVFF LEMRHMSGNV KDAIIEQLLP EDINITPDQL
     WSYIRENQDD VLFILDGLDE LSQTAKEVTD VVALIQGKIL RNCHVLVTSR PYHCVKDLEK
     CHEFYKIVGY TRENSVQFIE KYFNETPESA IKVVKQLECN PNLSRIIVNP LNNVLVCIVW
     EDNEGKLPSS RAELYEMIVY SVAKRYCAKK DIPLERNKIP PNIEEALKCL GKLSWEGLEQ
     DRLQFNIDDI KEKYGQNADD MLAIGLLTRD YSFSRIKRTC FCAFLHKTFQ EYLAAWYIRE
     LVKRESKEGK ECLRSVFGMT NSTSSNVDMK LMSANRERYR EVQNMLLAML GDSSGPLFEM
     FAEELRKDGV KGRTRIFCPL SVSCFLVELV KMPETLMGGM PYMSSDRHRY SPFRTFIPRR
     GTESVHIDFG NTDDFDSVPV ETMLEELSEI QSLQHVNINI GRNVGPDFSH YDSLFSVLLT
     RQSCLRSARL KIDQWIWSEE PRGFGNLTAT LTSISEHAAL EVVELEHPVN IECFGDGVCF
     DSPADTSVRL VALDVETMIC YPGPRPPCHA ICFVRPFFSW NVHNGVTLTK ALSALGSNVA
     LSRSPVEPVP PETLPKTSSA LPCYPSYHAV LQSDYRDDAL SRI
//