ID   C3ZNG5_BRAFL            Unreviewed;       797 AA.
AC   C3ZNG5;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Histidine-specific methyltransferase SAM-dependent domain-containing protein {ECO:0000259|Pfam:PF10017};
GN   ORFNames=BRAFLDRAFT_81965 {ECO:0000313|EMBL:EEN45918.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN45918.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN45918.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN45918.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995}.
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DR   EMBL; GG666651; EEN45918.1; -; Genomic_DNA.
DR   RefSeq; XP_002589907.1; XM_002589861.1.
DR   AlphaFoldDB; C3ZNG5; -.
DR   eggNOG; KOG1192; Eukaryota.
DR   InParanoid; C3ZNG5; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR019257; MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF145; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   Pfam; PF10017; Methyltransf_33; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        752..777
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          262..397
FT                   /note="Histidine-specific methyltransferase SAM-dependent"
FT                   /evidence="ECO:0000259|Pfam:PF10017"
FT   REGION          202..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   797 AA;  89737 MW;  1366BCE89DAE2237 CRC64;
     MQKWGIGKCH TIHQQAIHAA KDSEWTSIPK HVKQQVTDMR HDVWSKHQEN LLQQGQMLQL
     LEEEKCDLTW RSAMYNLPRG ILSFAVRASI DALPTLCNLT TWGKHTIVES IDPSLINATI
     YADIKCYTTN GGTIPVHTLP TTQKPDLVIY LPEQKTIHRF SYVRNLSFVV TRSANINRLY
     PYGIKDSRRA TTTQQWMLRQ ERMNQHSSGA SAAEKSNKRD DIRRDDVMKD LDVITRDVPS
     ALMPVVGGLT SRRKRVPYWV ATTSKTYLNW HKEHSVLQSH SDDIAAKTTS PVILVELGSG
     ASSKTRLILE AMLKRHRALT FVPVDVSKEH IEEVGQQLER DYEGLTVEPF GGLYMEGIRH
     LSTRKEPKML LFLGGSFGNI CIYEQVDMMK EVRAQLTGKL GLNLDFQRGE KFFFTDGPNW
     SCKWSLHQIR RLAEKSGFAV EDYWTNDAED YGVFCFTPVP SSSDRSFFES RAHVSTREDD
     SLLIIPVPMV FQWFLEGANN NLVIKYLGEK ETLLGVMGKT DVWLYRIDVL LGLPSPSMPN
     MVNVGGINAR EGSPLSEDLE LFMQTSGSAG VVVVSFGSQA KTISMERAEV MAAAFSRLRQ
     KVVWRYVGEK PAGLGNNTKL MSWLPQNDLL GHPKTRAFVT HAGSNGLYEA LYHGVPVVCT
     PLAGDQPGNA ARAVSKGLGV ILDFHTLTSE TMYQGITQVI TGNSYRETAA RLSRLHRDQP
     QPPMERAVWW IKHVIKHGGL PHLRARAVDL PWYQYYLLDV AAFLLAVCTA VLGTVWYSCS
     FICRKMCCKS GGKLKSQ
//