ID C3ZUH1_BRAFL Unreviewed; 1246 AA.
AC C3ZUH1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN ORFNames=BRAFLDRAFT_126584 {ECO:0000313|EMBL:EEN43810.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN43810.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN43810.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN43810.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
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DR EMBL; GG666683; EEN43810.1; -; Genomic_DNA.
DR RefSeq; XP_002587799.1; XM_002587753.1.
DR AlphaFoldDB; C3ZUH1; -.
DR STRING; 7739.C3ZUH1; -.
DR eggNOG; KOG1909; Eukaryota.
DR eggNOG; KOG3510; Eukaryota.
DR InParanoid; C3ZUH1; -.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central.
DR CDD; cd00116; LRR_RI; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027038; RanGap.
DR PANTHER; PTHR24113; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR24113:SF5; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF13516; LRR_6; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00368; LRR_RI; 11.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1246
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002937200"
FT DOMAIN 25..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 129..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 229..299
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 317..391
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 402..501
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 504..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1207
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 134919 MW; E72C57C009BB23C1 CRC64;
MAARCLARLN GVLFLAQFLL RSANGAVYRV RPQSAAVLHG QTVVLRCAFD KLTESENVIW
DGPPDFKVIS YDSKVLHVYN RHHIMGDAAR GEFNLEIRRA QLEDDGKYSC YTDPKAAASA
LLTVVVPMPT PPTITGGELM VTAGGQLSLT CRASGGHPAA RLTWLNGTRS LSTASVSAAM
EEDQTLELFL PRLTKWDNGA NFTCLADQGF PQLAKPKATS RILRVKYPPQ VQVPSPSVHV
REGEPASLSC MVDSNPTAEV TWRKVGGSLP SLKIPREHVL HLPKVSKQDS GMYQCEADNR
VPPLGLGTVN LQVYYGPIMD STMEEEVTML YGQDDQSLQC IAAGNPKPHI RWRRKDTSLY
WDNPLRFHRV RYDVQGTYQC VAASDGFQEV TKDVFIDVVG KPSIGNGPTT IAVAGGGTAR
LHCEILGDPL PGRVTWFWRN NKGVENVVMA TDYGLSIIEK PTKDGTSSTL LVKDVGISAE
GTYICQASNM FGEARREIRL EVKDTSTVSS TRPVPPVAKR LGHGTNDSGV EDLELQELDG
TLKPRPPPRA GKEWASVGLS YTGLAHVTAL PPYATVERHR PDGEDIRSRD DIPEETTMDT
DFTEYTEYIV FPKQSNFLGS ETRVRLVFLS RHDMAEPGVS EVVDLLAKTK VEQVNEVSFK
GRGLKLDKAE DAAEIVKAVL EAVDLQALRL EGNTVGVEAA KAIAAALEKH PEFERALWSD
MFTGRLRSEI PPSLESLGGA VITANAHLVE LDLSDNAFGP DGVKACRGLL TSKAVYTLEV
LKLNNNGLGV GGGQILSEAL IECHTASSTE GKPLALKVFI SGRNRLENPG AKALSKAFKV
IGTLEEVSMP QNGIQHLGIT ALAEAFSENK NLRVVNLNDN IFTEKGAESM AKKKRKVSLK
DFSLFSVSIH LESTIPAEIV KAVLEAVDLQ ALRLEGNTVG VEAAKAIAAA LEKHPEFEES
LGGAVITANA HLVELDLSDN AFGPDGVKAC RGLLTSKAVY TLEVLKLNNN GLGVGGGQIL
SEALIECHTA SSTEGKPLAL KVFISGRNRL ENPGAKALSK AFKVIGTLEE VSMPQNGIQH
LGITALAEAF SENKNLRVVN LNDNIFTEKG AESMAKELIL SYNEIRKDAA ILVAEAVEGK
EHLKKLDLNG NQLGEEGIEE LSGTLEAFDM VDVLGSLSDD EGDDIDDEED EEGEGEEEEE
EEGEAVDDPE LQVRGTAITP TRENQSPLKP NETEDLTEVM GKLALS
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