ID   C4FIL1_9AQUI            Unreviewed;       325 AA.
AC   C4FIL1;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE            EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN   ORFNames=SULYE_0396 {ECO:0000313|EMBL:EEP61092.1};
OS   Sulfurihydrogenibium yellowstonense SS-5.
OC   Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC   Sulfurihydrogenibium.
OX   NCBI_TaxID=432331 {ECO:0000313|EMBL:EEP61092.1, ECO:0000313|Proteomes:UP000005540};
RN   [1] {ECO:0000313|EMBL:EEP61092.1, ECO:0000313|Proteomes:UP000005540}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-5 {ECO:0000313|EMBL:EEP61092.1,
RC   ECO:0000313|Proteomes:UP000005540};
RA   Reysenbach A.-L., Heidelberg J.F., Nelson W.C.;
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC         Evidence={ECO:0000256|ARBA:ARBA00001893};
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC       subfamily. {ECO:0000256|ARBA:ARBA00010203}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEP61092.1}.
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DR   EMBL; ABZS01000025; EEP61092.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4FIL1; -.
DR   Proteomes; UP000005540; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002941; DNA_methylase_N4/N6.
DR   InterPro; IPR017985; MeTrfase_CN4_CS.
DR   InterPro; IPR001091; RM_Methyltransferase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR13370:SF32; DNA ADENINE METHYLTRANSFERASE YHDJ; 1.
DR   PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR   Pfam; PF01555; N6_N4_Mtase; 1.
DR   PRINTS; PR00508; S21N4MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00093; N4_MTASE; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EEP61092.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005540};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          107..319
FT                   /note="DNA methylase N-4/N-6"
FT                   /evidence="ECO:0000259|Pfam:PF01555"
SQ   SEQUENCE   325 AA;  37303 MW;  F86F20F9F31BCC31 CRC64;
     MLYPCLDFSP PRYVIIKLKE DRIMKKTSTY SFGVSKRESH NSSAFYRLEI YKNTESPLQI
     LNYVVETLRS EKNVNNLNNF QQNTMDWMNK IYCQSSENMF QIPDGSIALA FTSPPYNNGK
     EYDKNLNLKE YLLLLARVGK EVFRVLKKGG RYVINIANLG RKPYIPLHSL LYIIHAEIGF
     RPAGEIIWQK GKGASGNCAW GSWLSAKSPR IRDIHEYLLI FVKDDFSRPD KGVSTISKEE
     FLNYTISIWE VPPASAKKIG HPAPFPIELA SRVIKLFSYE NDVILDPFVG SGTTCVAAKK
     LKRNFVGYDI NEEYCKIALK RLQEE
//