ID C4FJ00_9AQUI Unreviewed; 599 AA.
AC C4FJ00;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:EEP60947.1};
GN Name=mrdA {ECO:0000313|EMBL:EEP60947.1};
GN ORFNames=SULYE_0540 {ECO:0000313|EMBL:EEP60947.1};
OS Sulfurihydrogenibium yellowstonense SS-5.
OC Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC Sulfurihydrogenibium.
OX NCBI_TaxID=432331 {ECO:0000313|EMBL:EEP60947.1, ECO:0000313|Proteomes:UP000005540};
RN [1] {ECO:0000313|EMBL:EEP60947.1, ECO:0000313|Proteomes:UP000005540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS-5 {ECO:0000313|EMBL:EEP60947.1,
RC ECO:0000313|Proteomes:UP000005540};
RA Reysenbach A.-L., Heidelberg J.F., Nelson W.C.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEP60947.1}.
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DR EMBL; ABZS01000038; EEP60947.1; -; Genomic_DNA.
DR RefSeq; WP_007546177.1; NZ_ABZS01000038.1.
DR AlphaFoldDB; C4FJ00; -.
DR OrthoDB; 9804124at2; -.
DR Proteomes; UP000005540; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005540};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..218
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 255..587
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 599 AA; 69078 MW; F686085F0EEF4520 CRC64;
MIKFNRITFL IFILTVFYFA LVGRLFYLQV IKGEHYREIS DRNYIKIFYS NPPRGKIYDR
NGVLLAYDVP TYSLIAFPYI VKKNYSMQEL KENLKNYLNI ELDEKTLNII EKNLYPSVVI
KKDLTQKDIE NFYNYNYLFN GFYLEVVPKR VYTEEANYLA HIIGYVGYPS ERELKENPNL
SPNILVGKAG VEKIYDSLLR GESGQKAVLV DAFGRQKKVL WEKDPRKGND IYLTIDIRIQ
KIAFEAFSSS KHPSGAVVLV DPNTYEILAS LSYPTYNLQK FYEGFSQEEW KELTENKYKP
LMNKVFLGKY PPGSIYKPLV SIAALEEGAI TPETRISSGP EFRIGKWVYR NWDKRGCGFI
NVSEALETSC DTFFYQVGLK LGVENIVKYS KLFGLGEKLN PDLEVKVATI PSKEWKRKVL
KQKWFHGDTV NLSIGQGYIT ITPFDATKIV VPIANGGYVL KPHILKAYFD NKSQRLVHTN
PEMIRKINIK KWNLDAVRYG MYLVVYGPSG TAKALKRVPV LNAGKTGTAQ VYSYDTRKKR
HHAWDFRDHA WFIDYAPYNK PKIAGVVFIE HGESGGKVAA PLMAYILKRI FKEKIIETE
//
