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Database: UniProt
Entry: C4GKN7_9NEIS
LinkDB: C4GKN7_9NEIS
Original site: C4GKN7_9NEIS 
ID   C4GKN7_9NEIS            Unreviewed;       519 AA.
AC   C4GKN7;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   05-JUL-2017, entry version 53.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EEP67296.1};
GN   ORFNames=GCWU000324_01542 {ECO:0000313|EMBL:EEP67296.1};
OS   Kingella oralis ATCC 51147.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Kingella.
OX   NCBI_TaxID=629741 {ECO:0000313|EMBL:EEP67296.1, ECO:0000313|Proteomes:UP000003009};
RN   [1] {ECO:0000313|EMBL:EEP67296.1, ECO:0000313|Proteomes:UP000003009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51147 {ECO:0000313|EMBL:EEP67296.1,
RC   ECO:0000313|Proteomes:UP000003009};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B.,
RA   Courtney L., Fronick C., Harrison M., Strong C., Farmer C.,
RA   Delahaunty K., Markovic C., Hall O., Minx P., Tomlinson C.,
RA   Mitreva M., Nelson J., Hou S., Wollam A., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Warren W., Chinwalla A., Mardis E.R.,
RA   Wilson R.K.;
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EEP67296.1}.
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DR   EMBL; ACJW02000003; EEP67296.1; -; Genomic_DNA.
DR   RefSeq; WP_003795984.1; NZ_GG665872.1.
DR   ProteinModelPortal; C4GKN7; -.
DR   STRING; 629741.GCWU000324_01542; -.
DR   EnsemblBacteria; EEP67296; EEP67296; GCWU000324_01542.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   Proteomes; UP000003009; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003009};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003009}.
FT   DOMAIN      215    345       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      427    496       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     223    230       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   519 AA;  58269 MW;  18E243F8044DB473 CRC64;
     MRLPEFWSQC LALLQSELSE QQFSRDIAPI TVGEQDGAWV LFAKNQFAAN LLRTQYARKI
     HEAAALIAPD APELLFQAGV GERVAMAQVP ADVVSPVNND RGSLKTANDN QAQTETAPAS
     EPTPSPARNK SAQDILAERM SNLRPAKQSP QRQPENAASK PSAIAAEQAR EAAEQRLNQT
     NLSPDYTFET LVEGKGNQLA ANVAKSIAEK PGDSMYNPFF VYGSTGLGKT HLVQAIGNEL
     LRLNPKAKVR YMHSDEYLKT FMATVRNKTW DTFKQQYLHY NLLIIDDIQF ISGKDRTMEE
     FFFLFEHFHS RDQQIILTCD QLPSSLEDMD KRLVSRFSWG MTIRLEPPEL EMRVDILERK
     AQAAGIMLEE DAATFIAQNV KQNVRELEGA LNRVIARCRF SKASTIDIDL ATDALQDIVA
     SNYKPITVEL IMKAVADHYH ISIRDILGKK RSRNLARPRQ IAMAITKELT NLSLPAIGDA
     FGGRDHTTVM HAVKTIAKLR QDEPELKQDY EKLLIVIQH
//
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