ID C4IM23_CLOBU Unreviewed; 587 AA.
AC C4IM23;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Integral membrane sensor signal transduction histidine kinase {ECO:0000313|EMBL:EEP52724.1};
GN ORFNames=CLP_0201 {ECO:0000313|EMBL:EEP52724.1};
OS Clostridium butyricum E4 str. BoNT E BL5262.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=632245 {ECO:0000313|EMBL:EEP52724.1, ECO:0000313|Proteomes:UP000003081};
RN [1] {ECO:0000313|EMBL:EEP52724.1, ECO:0000313|Proteomes:UP000003081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E4 str. BoNT E BL5262 {ECO:0000313|Proteomes:UP000003081};
RA Shrivastava S., Brinkac L.B., Brown J.L., Bruce D.B., Detter C.,
RA Green L.D., Munk C.A., Rogers Y.C., Tapia R., Sims D.R., Smith L.A.,
RA Smith T.J., Sutton G., Brettin T.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEP52724.1}.
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DR EMBL; ACOM01000007; EEP52724.1; -; Genomic_DNA.
DR RefSeq; WP_003410299.1; NZ_ACOM01000007.1.
DR AlphaFoldDB; C4IM23; -.
DR STRING; 1492.ATN24_15360; -.
DR eggNOG; COG2972; Bacteria.
DR HOGENOM; CLU_020473_6_1_9; -.
DR Proteomes; UP000003081; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEP52724.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000003081};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 319..371
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
SQ SEQUENCE 587 AA; 68098 MW; B2C3310B182117BD CRC64;
MKINRDLSIK KLTLLIFLSI YIIFLIVTAV NLYSYSRYEF NKTEKLIKNF NLNLSTQITQ
KLDNIIDVSK YPLIIPDIEK LNTTLSNNNT YDIEQYNYLL YLCDMMLIQN KTINGAYIFN
LNGNGVYTAR NNNNDLLKNP FHEKWFNTAV NSSNQVEIFS NFNATNVFRD TTKDDESLIA
ITRKIIDIKS QKTTGILLLT FSTDELLSLL TSDIPFNNEA VYLYDSENNL IIGTDDAEHQ
YNYSEYINQS STIPELVYSK DNEKHIVCYN NLQSSDWTII NTIPKDDAYH IDVLYLLFFL
SNLIFCLILF IVIYLFFLNR IFNPIKSLIA NMSSKVETNL NYNFAYNKND EIGILINSYN
DMKTRINTLI TINYKNQIEQ KELELKQLQN QINPHFIYNT LESIHMMAEI NDDPETSTMA
EYFGTIIRYS MNRRINTVKL KDEIEIINNY IYLQRIRFDS LFTIENLVTD DVLNCEIIKM
IIQPLIENSI YHGLSECDGN GKIIIQALKS NDNLIITVSD NGIGIDDKTL ESLNDYINDK
NELFNGIALR NINKRLKLNY GKEYGLEITS ILGKGTSMVL TIPYIIN
//
