ID C4JHH8_UNCRE Unreviewed; 977 AA.
AC C4JHH8;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1 {ECO:0000256|ARBA:ARBA00021935};
GN ORFNames=UREG_01341 {ECO:0000313|EMBL:EEP76492.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP76492.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria.
CC {ECO:0000256|ARBA:ARBA00002238}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476615; EEP76492.1; -; Genomic_DNA.
DR RefSeq; XP_002541825.1; XM_002541779.1.
DR AlphaFoldDB; C4JHH8; -.
DR STRING; 336963.C4JHH8; -.
DR GeneID; 8442670; -.
DR KEGG; ure:UREG_01341; -.
DR VEuPathDB; FungiDB:UREG_01341; -.
DR eggNOG; KOG0752; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_012680_0_0_1; -.
DR InParanoid; C4JHH8; -.
DR OMA; RIRICQA; -.
DR OrthoDB; 261981at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IEA:UniProt.
DR CDD; cd09917; F-box_SF; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF59; MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000002058};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..46
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REPEAT 104..136
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 137..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 401..436
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 474..506
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 507..539
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 670..768
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 779..865
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 872..967
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 977 AA; 106400 MW; 6AA758D0E330880D CRC64;
MASLDLLPTE LLNLIAQKLH VEHISNLLRT SKRLYNALND ELYREASRRD NDEYGQPVSL
IHAASFGEPA SFDGLLSRVK DINSPIVDLE GYPSYRLPIS KGVTRITILQ AVSAMGKENL
VELLIAKGVD TEVRDNGQQT ALHLAVILKQ TAVVKSLIEG GANVLALHGA QNTALVYALQ
YGSLAIARML IAAGGANVEL PAGPSNPVSQ TVAYMDLSLV KQLLETSSAF FPEPCLTDAL
PSAIKTGNVD IIQYLLDAGA KATPDALSEA CAADNLPVIK LLIQAGANVR GRQRTGATAL
HSVCSFEAAK LLFNEAPDLG RLLAAHQPAV EHVYRTYSLN QNLDIILLVL FLLWKGPRDQ
DPEDSGNRMR AIHYAAQYGH EAVLRSILAQ QKWQVSTLSC TGATALHYAA ASTSESRLNC
VRLLVEGGVD MAVMDQLGNT ALKSVFLNGY HPLNATVAEY LVRAGANPSQ RQQNDKSPLH
DALYHSDSES ALVLIQAGAD ISAMDPCGMQ PLHFAALFGC ADIVTELAQR GVNLSARDNR
GYTPLHLAIS QGFEKYRNRE DFLVSVERVI TRKYSHAHTS HADPEALRGS RYLAVIKALC
YTGANINAQA TSMNLSPADF VGMQRFCWNG FARNEGPSTE TEQVDETLQS ADEVRKIWWK
LAEYLNWQRG QRYQVVAAGA IAGLVSRFCV APLDVVKIRL QLQIHSLSDP LSHRHIHGPV
YKGTISTLKA IVREEGITGL WKGNIPAELL YVFYGGIQFT TYRTVTQALH TLPTAHRLPQ
PAESFLSGAV AGGIATLTTY PFDLLRTRFA AQGNIKIYPS LLSAVRTIHS HEGYPGFFRG
ASAAVAQIVP YMGLFFATYE SVRVPVAQLE LPFGSGDATA GVIASVLAKT GVFPLDLVRK
RLQVQGPTRS RYIHQNIPEY SGVWSTIKSV VRDGGVRGLY RGLTVSLIKA APASAVTMWT
YERVLKTLKE MNADPVR
//
