ID   C4JPH6_UNCRE            Unreviewed;       506 AA.
AC   C4JPH6;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Aminoglycoside phosphotransferase domain-containing protein {ECO:0000259|Pfam:PF01636};
GN   ORFNames=UREG_03148 {ECO:0000313|EMBL:EEP78302.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP78302.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC       {ECO:0000256|ARBA:ARBA00006219}.
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DR   EMBL; CH476616; EEP78302.1; -; Genomic_DNA.
DR   RefSeq; XP_002543631.1; XM_002543585.1.
DR   AlphaFoldDB; C4JPH6; -.
DR   GeneID; 8437779; -.
DR   KEGG; ure:UREG_03148; -.
DR   VEuPathDB; FungiDB:UREG_03148; -.
DR   eggNOG; ENOG502SNEF; Eukaryota.
DR   HOGENOM; CLU_030115_0_0_1; -.
DR   InParanoid; C4JPH6; -.
DR   OMA; NDENWVF; -.
DR   OrthoDB; 2540526at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR21310; AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED; 1.
DR   PANTHER; PTHR21310:SF15; APH DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        484..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          264..308
FT                   /note="Aminoglycoside phosphotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF01636"
SQ   SEQUENCE   506 AA;  58878 MW;  485D70EBA40C5415 CRC64;
     MDQLTRHLLD KEVKKFINSI EPSLVCKLAS SLHPEKKPCH VFSDPQKGSY NICFPVVFTD
     SEDQISDVES TQSAERWMIR IPLLPRLAFP EEKMRGEIAT MKYIAEKTTI PIPHLFKYSI
     NRDNILNLPF MALEYIAGKT LHGIDVPCLP DELKSHLFDQ LADVYIQLYH QQFDHVGALT
     LDSNDNWVFQ HNRPLTIELN DQELSGMKSS EIIPAHQTYN STIDYVYAVL KLIFNDFYHG
     KDSVFNKEDA RNYLYGIFAS QGIVMEWVDP KDNHGPFILM HGDLRPPNVF VDADLNIISI
     IDWEWSHTVP PQMFVPPSWI TGQELPAATK KPYDFAFTVY VSQFQRAARE WEDKHYNPDK
     KLKFILPLVK LWSKHLMSDT FFIAYALLKP CYFGNVYWNL LDNMYYGEDS DKRVESFFKL
     RKKQEEELQR VLSNLEDFEK ELALEGLDPL KPPTLDPAKG KEVAAIHQVW RKPNLERIVG
     LFRRWLPCSL VGVSVFVCCI IVKRRR
//