ID   C4JRT5_UNCRE            Unreviewed;       535 AA.
AC   C4JRT5;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN   ORFNames=UREG_05174 {ECO:0000313|EMBL:EEP80332.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP80332.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CH476617; EEP80332.1; -; Genomic_DNA.
DR   RefSeq; XP_002584485.1; XM_002584439.1.
DR   AlphaFoldDB; C4JRT5; -.
DR   GeneID; 8438146; -.
DR   KEGG; ure:UREG_05174; -.
DR   VEuPathDB; FungiDB:UREG_05174; -.
DR   eggNOG; KOG2533; Eukaryota.
DR   HOGENOM; CLU_001265_0_0_1; -.
DR   InParanoid; C4JRT5; -.
DR   OMA; AWSFYLL; -.
DR   OrthoDB; 1749674at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR43791; PERMEASE-RELATED; 1.
DR   PANTHER; PTHR43791:SF33; VITAMIN H TRANSPORTER 1; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        129..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        184..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        217..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        305..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        339..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        432..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        477..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          35..503
FT                   /note="Major facilitator superfamily (MFS) profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
SQ   SEQUENCE   535 AA;  58705 MW;  BA90302633B8673B CRC64;
     MQEEPATVPV FKESGKSSIE ETLPNGIVDC ETADAPTAAE IDRIYRKLDW RIIPPFWTLY
     FLCASIRSTV GLSQTMNLAE KHDLGSVLRM TPQQSSTSLA LFYVCYVVFD LPSNLIMTRL
     SPRVWMSRIV IGVGVIGSCM AAVQAAWSLY LLRLLLGVVM AGLWPGMAYY LTLFYPPSRT
     GKRIGLYFTA AQVSAAVVGL VSAGFQKMDG ARGIVGFRWM FLVYGLCGVV TGISLLWWLP
     ERPLPPGEAP MPPGKLTRFL PRTPPALTGR DAAIHYRDLK RVYHRTQWTL SDLARVLMDW
     RLWPLLIMYF GVVGVGIGVQ SYGTVIIRST NPSLTSIELS LLFAPIWISD LLAILLITPL
     SDRFHHHRAL FFSLPATLQI LGLLLTTYAG NPTTNPWPRY AGLLIVGFGL GPTVPIAMTW
     TSEVFQPRHG EVGVAAASAV VSGLGNLGSI VSTYALYAGW ESDRVATGGR QYRKSNWVLI
     GMLLGSVGAA VVMQVLLRVV DGKKGAAGDG GDGAAKREVR QRGLEGVWFL RWLNR
//