GenomeNet

Database: UniProt
Entry: C4JT07_UNCRE
LinkDB: C4JT07_UNCRE
Original site: C4JT07_UNCRE 
ID   C4JT07_UNCRE            Unreviewed;      1173 AA.
AC   C4JT07;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   13-SEP-2023, entry version 75.
DE   RecName: Full=Ras guanine-nucleotide exchange protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=UREG_05596 {ECO:0000313|EMBL:EEP80754.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP80754.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476617; EEP80754.1; -; Genomic_DNA.
DR   RefSeq; XP_002584907.1; XM_002584861.1.
DR   AlphaFoldDB; C4JT07; -.
DR   STRING; 336963.C4JT07; -.
DR   GeneID; 8441102; -.
DR   KEGG; ure:UREG_05596; -.
DR   VEuPathDB; FungiDB:UREG_05596; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   HOGENOM; CLU_002116_1_0_1; -.
DR   InParanoid; C4JT07; -.
DR   OMA; CVRGAGD; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          67..133
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          728..848
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          881..1124
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          294..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          515..595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          669..712
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..595
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..684
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        698..712
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1173 AA;  130240 MW;  26BF421A794ED4DF CRC64;
     MDEYIAPLNL SHGKAPSQLR HGSFSTRTIS NQRLFSALKT QLRMTPPLTP HSSREDMVDR
     SNSERSAFPN YLRAFYPFHP GAPISSATVT LPLDQGDLVL VHSVHTNGWA DGTLLDTGAR
     GWLPTNYCEA YDQQLMRPLL KALMDFWDVI RAGSCATLHQ FGNQDYMKGI IAGVRFLLEK
     SECLKREDEL VQRLVGLRRN RKALLSDLSS LAKMAKNLRD IANGAPLDDS LDNVFDQMLL
     KAFRIVTRGV RFMDVWNEEV GLSRVMEEMS PGGSITRMYD EPLTPPVDSS FRISDSAWGS
     TPESSVSAAS RVESRARSNR SFGSRAPSQL SYNDSNQHRR SLIQAKRVSV SHRISYTATS
     STVRNPNFAS ERLNAAIDDF LGVLGSFIGL HLHSRSSTEL IVTTQQAVQS CRVLLSVVEE
     VWEHDLHRSE ALEQAKDTMY ERITELVHAA RDAFRPANGS DDETIFMPDE GKRLVDAATV
     CVRGAGDCVA KARQVLEQVG DFEIENIEAV GLGISTADSD KSDSSPDDFG GALDTETPKI
     LSANGDSHKS DTNERSTRLP PPLQIPSCSL STSSLTPSLT TDGGTTPSPS FITTAIDTPT
     STLDEPFTAA FSSFTDLDDS LLGATDLGET QDPPIYIHAK NKEEKAESQG EGTRGVTSVE
     TERTCVDTID DSQVTISSRP STAVDDSQPP PPPLKDDVAS IHHSDGEQGE DSEECILEKT
     FAHELMFKDG QVIGGSLRAL IEKLTAHEST PDAMFVSTFY LTFRHFATPV EFAEALIDRY
     DYIGDNAKAG GPVRLRVSNI FKGWLEAHWR HDCDDSALPC ILSFARSKLM DTLPTAGQRL
     IELVEEVSIL TVPSCHDWFH QWARQILRLL NIQTITILDF DPMELARQLT LKESSIFCAI
     LPEELLGTEW MKKTGSLAVN VRAMSTLSTD LANLVADCIL QLEEPKKRAL VIKQWVKIAS
     KCLELNNYDS LMAIICSLNS STISRLKRTW ELVSQKTKNT LETLREIVDV SRNYAVLRHR
     IQNHVPPCLP FVGTYLTDLT FVDHGNQDTR TLTADGGSIE VINYDKHMKT AKIISELQRF
     QIPYRLTEVP ELQTWIQDQL VRVRSAGEKG FQNYYRRSLI LEPRERSTQR NSPGDANAFS
     IFSRENAKEK FDFLAWTQSA KTKAAAAAAA ATS
//
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