ID C4JT07_UNCRE Unreviewed; 1173 AA.
AC C4JT07;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 13-SEP-2023, entry version 75.
DE RecName: Full=Ras guanine-nucleotide exchange protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=UREG_05596 {ECO:0000313|EMBL:EEP80754.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP80754.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476617; EEP80754.1; -; Genomic_DNA.
DR RefSeq; XP_002584907.1; XM_002584861.1.
DR AlphaFoldDB; C4JT07; -.
DR STRING; 336963.C4JT07; -.
DR GeneID; 8441102; -.
DR KEGG; ure:UREG_05596; -.
DR VEuPathDB; FungiDB:UREG_05596; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002116_1_0_1; -.
DR InParanoid; C4JT07; -.
DR OMA; CVRGAGD; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002058};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 67..133
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 728..848
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 881..1124
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 294..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 130240 MW; 26BF421A794ED4DF CRC64;
MDEYIAPLNL SHGKAPSQLR HGSFSTRTIS NQRLFSALKT QLRMTPPLTP HSSREDMVDR
SNSERSAFPN YLRAFYPFHP GAPISSATVT LPLDQGDLVL VHSVHTNGWA DGTLLDTGAR
GWLPTNYCEA YDQQLMRPLL KALMDFWDVI RAGSCATLHQ FGNQDYMKGI IAGVRFLLEK
SECLKREDEL VQRLVGLRRN RKALLSDLSS LAKMAKNLRD IANGAPLDDS LDNVFDQMLL
KAFRIVTRGV RFMDVWNEEV GLSRVMEEMS PGGSITRMYD EPLTPPVDSS FRISDSAWGS
TPESSVSAAS RVESRARSNR SFGSRAPSQL SYNDSNQHRR SLIQAKRVSV SHRISYTATS
STVRNPNFAS ERLNAAIDDF LGVLGSFIGL HLHSRSSTEL IVTTQQAVQS CRVLLSVVEE
VWEHDLHRSE ALEQAKDTMY ERITELVHAA RDAFRPANGS DDETIFMPDE GKRLVDAATV
CVRGAGDCVA KARQVLEQVG DFEIENIEAV GLGISTADSD KSDSSPDDFG GALDTETPKI
LSANGDSHKS DTNERSTRLP PPLQIPSCSL STSSLTPSLT TDGGTTPSPS FITTAIDTPT
STLDEPFTAA FSSFTDLDDS LLGATDLGET QDPPIYIHAK NKEEKAESQG EGTRGVTSVE
TERTCVDTID DSQVTISSRP STAVDDSQPP PPPLKDDVAS IHHSDGEQGE DSEECILEKT
FAHELMFKDG QVIGGSLRAL IEKLTAHEST PDAMFVSTFY LTFRHFATPV EFAEALIDRY
DYIGDNAKAG GPVRLRVSNI FKGWLEAHWR HDCDDSALPC ILSFARSKLM DTLPTAGQRL
IELVEEVSIL TVPSCHDWFH QWARQILRLL NIQTITILDF DPMELARQLT LKESSIFCAI
LPEELLGTEW MKKTGSLAVN VRAMSTLSTD LANLVADCIL QLEEPKKRAL VIKQWVKIAS
KCLELNNYDS LMAIICSLNS STISRLKRTW ELVSQKTKNT LETLREIVDV SRNYAVLRHR
IQNHVPPCLP FVGTYLTDLT FVDHGNQDTR TLTADGGSIE VINYDKHMKT AKIISELQRF
QIPYRLTEVP ELQTWIQDQL VRVRSAGEKG FQNYYRRSLI LEPRERSTQR NSPGDANAFS
IFSRENAKEK FDFLAWTQSA KTKAAAAAAA ATS
//