ID C4JW81_UNCRE Unreviewed; 675 AA.
AC C4JW81;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=FAD/NAD(P)-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=UREG_06823 {ECO:0000313|EMBL:EEP81958.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP81958.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004721}.
CC -!- SIMILARITY: Belongs to the FAD-binding monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00010139}.
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DR EMBL; CH476618; EEP81958.1; -; Genomic_DNA.
DR RefSeq; XP_002583856.1; XM_002583810.1.
DR AlphaFoldDB; C4JW81; -.
DR STRING; 336963.C4JW81; -.
DR GeneID; 8437350; -.
DR KEGG; ure:UREG_06823; -.
DR VEuPathDB; FungiDB:UREG_06823; -.
DR eggNOG; ENOG502SHCE; Eukaryota.
DR HOGENOM; CLU_006937_8_2_1; -.
DR InParanoid; C4JW81; -.
DR OMA; HIAYIIA; -.
DR OrthoDB; 2785305at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR43098:SF2; FAD-BINDING MONOOXYGENASE AUSB-RELATED; 1.
DR PANTHER; PTHR43098; L-ORNITHINE N(5)-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 75042 MW; 5BD99FF10760510B CRC64;
MDTLFGAQVS PKTMAQAPTS NEPFVLNGTK ADAAGDTANC NADAINPSKA EQIRQKYAEE
REKRLRPDGL EQYIGLSNTD DQSLKRLLHD QWDDGTTPSL PLEEGARYKI VIVGAGIGGL
LFAVRLQDMG FKPEDMVIVD SAAGFGGTWY WNRYPGLMCD TESYIFMPLL EETGYMPKHK
YAYGQELREH ANRIAERWSL TDRAMFRTRF EQCAWNDETL EWTVDLTQRP PGGHSISAKI
HADFVILCPG PLNRPKILRL PGVGTFQGQS FHASRWDYSV TGGTQEKPDL TNLQDKRVGI
IGTGATSVQA IPHLAKWSKQ LYVFQRTPAS VDVRNQRPTN LQDWAEVTRP GAGWQLARKP
QFQHLHLPPS HRAPRSTWSL TDGPTSQSMS VLSGGPTHVT MDNIAEYTAA IHARDLVRSE
RIRARVDQII KDANAASKLK AWYSAWCKRP AFHDDYLPSF NLPNVTLVDT NGKGVQRITD
SGLVANDTHF PLDVLIFASG FELKPGQSPG ASTNARVFGR GGMCLDEKWV DRLSTLHGLM
TSDFPNLFFT GFVQSGFSPN YTTCLETSAR HTAFLIAECA KRAGPEGRKV VMEPTPEAER
AWEKRIAAGA LIRAPVVGCT PSYWNAEGKL DQTTPEEKEK RRGAGPCPRG MNDFMDVLQE
WRDAGDFGDL RIDVV
//
