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Database: UniProt
Entry: C4K1R3
LinkDB: C4K1R3
Original site: C4K1R3 
ID   RNC_RICPU               Reviewed;         227 AA.
AC   C4K1R3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   03-SEP-2014, entry version 36.
DE   RecName: Full=Ribonuclease 3;
DE            EC=3.1.26.3;
DE   AltName: Full=Ribonuclease III;
DE            Short=RNase III;
GN   Name=rnc; OrderedLocusNames=RPR_04080;
OS   Rickettsia peacockii (strain Rustic).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=562019;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rustic;
RX   PubMed=20027221; DOI=10.1371/journal.pone.0008361;
RA   Felsheim R.F., Kurtti T.J., Munderloh U.G.;
RT   "Genome sequence of the endosymbiont Rickettsia peacockii and
RT   comparison with virulent Rickettsia rickettsii: identification of
RT   virulence factors.";
RL   PLoS ONE 4:E8361-E8361(2009).
CC   -!- FUNCTION: Digests double-stranded RNA. Involved in the processing
CC       of primary rRNA transcript to yield the immediate precursors to
CC       the large and small rRNAs (23S and 16S). Processes some mRNAs, and
CC       tRNAs when they are encoded in the rRNA operon. Processes pre-
CC       crRNA and tracrRNA of type II CRISPR loci if present in the
CC       organism (By similarity).
CC   -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC       phosphomonoester.
CC   -!- COFACTOR: Mg(2+) (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
CC   -!- SIMILARITY: Contains 1 RNase III domain.
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DR   EMBL; CP001227; ACR47513.1; -; Genomic_DNA.
DR   RefSeq; WP_012736743.1; NC_012730.1.
DR   RefSeq; YP_002916562.1; NC_012730.1.
DR   STRING; 562019.RPR_04080; -.
DR   EnsemblBacteria; ACR47513; ACR47513; RPR_04080.
DR   GeneID; 7942617; -.
DR   KEGG; rpk:RPR_04080; -.
DR   PATRIC; 17899171; VBIRicPea48268_0799.
DR   eggNOG; COG0571; -.
DR   HOGENOM; HOG000246808; -.
DR   KO; K03685; -.
DR   OMA; TFKDQEL; -.
DR   OrthoDB; EOG6T1WVS; -.
DR   BioCyc; RPEA562019:GJD7-519-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   Gene3D; 3.30.160.20; -; 1.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRNA-bd_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   PANTHER; PTHR11207; PTHR11207; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF14622; Ribonucleas_3_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 1.
DR   SUPFAM; SSF69065; SSF69065; 1.
DR   TIGRFAMs; TIGR02191; RNaseIII; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW   Metal-binding; mRNA processing; Nuclease; RNA-binding;
KW   rRNA processing; rRNA-binding; tRNA processing.
FT   CHAIN         1    227       Ribonuclease 3.
FT                                /FTId=PRO_1000202845.
FT   DOMAIN        4    133       RNase III.
FT   DOMAIN      158    226       DRBM.
FT   ACT_SITE     50     50       Potential.
FT   ACT_SITE    122    122       By similarity.
FT   METAL        46     46       Magnesium (By similarity).
FT   METAL       119    119       Magnesium (By similarity).
FT   METAL       122    122       Magnesium (By similarity).
SQ   SEQUENCE   227 AA;  26051 MW;  6193611E507843BE CRC64;
     MESFEKLEKL LSYSFKNKEL LIEALSHPSL RQHHEYKDDK DYERLEFLGD AVLNLVITEI
     LFRNFANYNE GNLAKIRSYL VCKETICMVG AKLTLKNYII MTHGEEVAGG RDNLNNIENA
     TEALIAAIYL DSNIETTHDI IEKLWAEFIK VQNLTDYDPK TALQEWAQAS DHHLPIYRLI
     KREGASHAST FTVLVKVKDY EQTGTGHAIK EAEKNAARSL LHRLKND
//
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