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Database: UniProt
Entry: C4K7P5_HAMD5
LinkDB: C4K7P5_HAMD5
Original site: C4K7P5_HAMD5 
ID   C4K7P5_HAMD5            Unreviewed;       547 AA.
AC   C4K7P5;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325, ECO:0000256|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342, ECO:0000256|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245, ECO:0000256|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810,
GN   ECO:0000313|EMBL:ACQ68588.1};
GN   OrderedLocusNames=HDEF_2009 {ECO:0000313|EMBL:ACQ68588.1};
OS   Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; aphid secondary symbionts; Candidatus Hamiltonella.
OX   NCBI_TaxID=572265 {ECO:0000313|EMBL:ACQ68588.1, ECO:0000313|Proteomes:UP000002334};
RN   [1] {ECO:0000313|EMBL:ACQ68588.1, ECO:0000313|Proteomes:UP000002334}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5AT {ECO:0000313|Proteomes:UP000002334};
RX   PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA   Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT   "Hamiltonella defensa, genome evolution of protective bacterial
RT   endosymbiont from pathogenic ancestors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000256|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000256|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810};
CC       Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01810}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010527, ECO:0000256|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP001277; ACQ68588.1; -; Genomic_DNA.
DR   RefSeq; WP_015874343.1; NC_012751.1.
DR   AlphaFoldDB; C4K7P5; -.
DR   STRING; 572265.HDEF_2009; -.
DR   GeneID; 66261565; -.
DR   KEGG; hde:HDEF_2009; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_3_0_6; -.
DR   OMA; INPVAGC; -.
DR   Proteomes; UP000002334; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd20070; 5TM_YidC_Alb3; 1.
DR   CDD; cd19961; EcYidC-like_peri; 1.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR028055; YidC/Oxa/ALB_C.
DR   InterPro; IPR047196; YidC_ALB_C.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   NCBIfam; TIGR03593; yidC_nterm; 1.
DR   NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR   PANTHER; PTHR12428:SF65; CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12428; OXA1; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW   Rule:MF_01810};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01810};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01810};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW   Rule:MF_01810};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_01810};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_01810};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01810}.
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT   TRANSMEM        354..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT   TRANSMEM        417..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT   TRANSMEM        500..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT   DOMAIN          62..343
FT                   /note="Membrane insertase YidC N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14849"
FT   DOMAIN          354..533
FT                   /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02096"
SQ   SEQUENCE   547 AA;  62248 MW;  FEC2C68AEDEAB101 CRC64;
     MDSQRNLLLI AFFFVSFMIW QTWQVDHNPL KAVENGTALV TNNNGTETST LVPLSNTQGQ
     KITVTTDVLS LTIDTQGGDI QQANLLAYPD TLGSKKSFQL LESTPDFVYE AQSGLTGKNG
     PDNPLNGHRP VYSVKQPHFV LPEGQNELQI PLTFTDKNGL VLTKTFILKR NDYAIRVLYR
     INNASSTPLE FNFFGQLKQS TQLPKHRDTA SSNFALHTYR GAAYSSKEDK YKKYSFSDIE
     DANLNITTQG GWVAMLQQYF ATAWIPNAGE THDFYSRHLG HGLVASGFKS LPVLVNPGEQ
     KELSATLWVG PELQDKMAVI APHLDLTVDY GWLWFISQPL FKLLKFIHGF VGNWGLSIIL
     ITFIVRGIMY PLTKAQYTSM AKMRMLQPKL TEMRERIGDD RQRMSQEMMA LYKSEKVNPL
     GGCLPLIIQM PIFLALYYML MGSVELRHAP FILWIHDLSA QDPYYILPIL MGLTMYFIQK
     MSPSTITDPM QKKIMNFMPV IFTVFFLWFP SGLVLYYIVS NLVTIIQQQL IYRGLESRGL
     HNRDKKK
//
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