ID C4L6U3_EXISA Unreviewed; 895 AA.
AC C4L6U3;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Peptidase S8 and S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:ACQ70036.1};
GN OrderedLocusNames=EAT1b_1108 {ECO:0000313|EMBL:ACQ70036.1};
OS Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b).
OC Bacteria; Bacillota; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX NCBI_TaxID=360911 {ECO:0000313|EMBL:ACQ70036.1, ECO:0000313|Proteomes:UP000000716};
RN [1] {ECO:0000313|EMBL:ACQ70036.1, ECO:0000313|Proteomes:UP000000716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1283 / AT1b {ECO:0000313|Proteomes:UP000000716};
RX PubMed=21460088; DOI=10.1128/JB.00303-11;
RA Vishnivetskaya T.A., Lucas S., Copeland A., Lapidus A., Glavina Del Rio T.,
RA Dalin E., Tice H., Bruce D.C., Goodwin L.A., Pitluck S., Saunders E.,
RA Brettin T., Detter C., Han C., Larimer F., Land M.L., Hauser L.J.,
RA Kyrpides N.C., Ovchinnikova G., Kathariou S., Ramaley R.F., Rodrigues D.F.,
RA Hendrix C., Richardson P., Tiedje J.M.;
RT "Complete genome sequence of the Thermophilic Bacterium Exiguobacterium sp.
RT AT1b.";
RL J. Bacteriol. 193:2880-2881(2011).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; CP001615; ACQ70036.1; -; Genomic_DNA.
DR RefSeq; WP_012727155.1; NC_012673.1.
DR AlphaFoldDB; C4L6U3; -.
DR STRING; 360911.EAT1b_1108; -.
DR MEROPS; S08.004; -.
DR KEGG; eat:EAT1b_1108; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_323576_0_0_9; -.
DR Proteomes; UP000000716; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07484; Peptidases_S8_Thermitase_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR041498; Big_6.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034084; Thermitase-like_dom.
DR PANTHER; PTHR43399:SF5; CELL WALL-ASSOCIATED PROTEASE; 1.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR Pfam; PF17936; Big_6; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..895
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002940247"
FT DOMAIN 451..683
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 816..894
FT /note="Bacterial Ig"
FT /evidence="ECO:0000259|Pfam:PF17936"
FT ACT_SITE 459
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 496
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 649
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 895 AA; 96150 MW; 3BBEFDBF3B8D09CB CRC64;
MKARFKQFVA MVTVLVLVLS FLPPALADSG NGMTNATLLT PGEAVEFTTG TDPVNTYWFK
MERETSAMTH MEVTFESSKL ANISVYPSAD MAAKDETFDR YRASATKEEE EQTAKIEFPF
AWEGPYYIKV EYMPMDLGEE IPGEEIPGDV LPVDGEEPTD PGMPDLASDI KLVVNPVKLP
VKYEQVGGDM CAVESIVQPA PERDSMLKLI RRVQSEVLGT SQKGRDLSAL YYRASPYIVK
AITFDGEKRK AALTDLKTLR PLLTALVDKK AYTLKTQDAA AINRLHALVD ASVPTALQGE
IGEIATALEM DSLAGTPVTD LFGKVGMTIQ TDGSDAPRYI VKYKSSPNTS IGKMNAMSDV
SAERIAIGKP SDYFALVDVE EASTKMQAQA KSTLESDRNV EYIEPVQTYQ SFATDVSLDY
QWAINQKSVL EPFANAGIGL DKYEALNLPK RSIKVAVLDT GVDHRLLDLK GKVDVANAKN
FVDPNGEGDA IDDHGHGTHV AGVIGATRDN GVSMRGIVPN VSILPVKVLD AGGSGDTDQI
ALGIKYAVDA GAKVINMSLG GNESRTLGYM LKYAYDRGVV IVAATGNDAQ SRVSYPASSK
YTISVGATNA FGIVSDYSNY GIGVDVVAPG SKVASLVPDG NVVYMDGTSM ATPHVAATVA
LLKSYHPDLS VEDVRTLLQR TADPIAFSGG DAPYDPRMSD GFEYVLEELG MTLPAYYNPV
SGFGKANVYR AESMLKLNAS GANAQDNSTT FKAKVTSGTT VRVYKGEKLI GRGTSKQTMA
AFSIQPQKAG AVLRVVYTNG KYETSERVVV KAGARPGQPT VNTLRSGAKS VTGRGEAGMR
VVVRNSNYQL LGRGTVLPNG TFSVKTRALK KGETINVHIE DLKGRPGKMS KTTVR
//
