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Database: UniProt
Entry: C4MJI8_9HIV1
LinkDB: C4MJI8_9HIV1
Original site: C4MJI8_9HIV1 
ID   C4MJI8_9HIV1            Unreviewed;       231 AA.
AC   C4MJI8;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   08-NOV-2023, entry version 42.
DE   RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE   AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:ACI03531.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ACI03531.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ACI03531.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=60203906 {ECO:0000313|EMBL:ACI03531.1};
RX   PubMed=19552592; DOI=10.1089/aid.2009.0014;
RA   Hudelson S.E., Marlowe N., Huang W., Bruce R., Church J.D., Husnik M.,
RA   Donnell D., Coates T., Jackson J.B., Chesney M., Koblin B., Eshleman S.H.;
RT   "Analysis of HIV type 1 gp41 and enfuvirtide susceptibility among men in
RT   the United States who were HIV infected prior to availability of HIV entry
RT   inhibitors.";
RL   AIDS Res. Hum. Retroviruses 25:701-705(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC       membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004563}.
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DR   EMBL; EU709664; ACI03531.1; -; Genomic_DNA.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR   Gene3D; 1.10.287.210; -; 1.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 1.
DR   Gene3D; 1.20.5.490; Single helix bin; 1.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR000328; GP41-like.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 1.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Viral envelope protein {ECO:0000313|EMBL:ACI03531.1};
KW   Virion {ECO:0000256|ARBA:ARBA00022844}.
FT   TRANSMEM        34..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..33
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   DOMAIN          52..227
FT                   /note="Retroviral envelope protein GP41-like"
FT                   /evidence="ECO:0000259|Pfam:PF00517"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACI03531.1"
FT   NON_TER         231
FT                   /evidence="ECO:0000313|EMBL:ACI03531.1"
SQ   SEQUENCE   231 AA;  26593 MW;  09A362CE44F172E6 CRC64;
     WRSELYKYKV VRIEPLGVAP TKAKRRVVQR EKRAVGIGAL FLGFLGAAGS TMGAASLTLT
     VQARLLLSGI VQQQNNLLRA IEAQQHLLQL TVWGIKQLQA RVLAVERYLK DQQLLGIWGC
     SGKLICTTAV PWNASWSNKS LDYIWDNMTW MEWEREIDNY TGLIYSLIEE SQNQQEKNEQ
     DLLALDKWAD LWSWFNITNW LWYIRLFIMI VGGLIGLRII FTVLSIVNRV X
//
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