ID C4PBS2_CHICK Unreviewed; 868 AA.
AC C4PBS2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ACR26582.1};
RN [1] {ECO:0000313|EMBL:ACR26582.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=505 {ECO:0000313|EMBL:ACR26582.1};
RX PubMed=20483729; DOI=10.4049/jimmunol.0903092;
RA Downing T., Lloyd A.T., O'Farrelly C., Bradley D.G.;
RT "The differential evolutionary dynamics of avian cytokine and TLR gene
RT classes.";
RL J. Immunol. 184:6993-7000(2010).
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; FJ915256; ACR26582.1; -; Genomic_DNA.
DR AlphaFoldDB; C4PBS2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 3.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 653..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 705..846
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 159..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 868 AA; 98348 MW; D36F5D7B86518E2E CRC64;
MRILIGSLYF YFISFLFSKV NGFLTQRTSP VSSFPFYNYS YLNLSSVSQA QAPKTARALN
FSYNAIEKIT KRDFEGFHVL EVLDLSHNHI KDIEPGAFEN LLSLVSVDLS FNDKNLLVSG
LAPHLKLIPT SGASGPSQIY MYFQKSAEAA LEPSAPAELL PHLEDPPNPG NVNPRFRQRR
TEENKTSPPA ATLRPDLCGA PINGLLDLSR TKLSNEELTA KLDADLCQAQ LGTVLEFNIS
HSDLEMDLLS LFILFLPMKD IQSVDASYNR ITINNIDVEA ICHFPFSNFS FLNISNNPIN
SLETVCLPES ITVIDLSFTN ISTIPANFAK KLSKLERMYV QGNQLIYTVR PENPSATPRP
PPGTVQISAI SLVRNQAGTP IESLPESVKH LKVSNCSIVE LPEWFANRMQ ELLFLDLSSN
RISMLPDLPI SLQQLDISNS DIKIIPPRFK SLSNLTVFYI QNNKLTEMHP EYFPSTLTTC
DISKNKLKVL SLTKALENLE SLNVSGNLIT RLEPACQLPS LTNLDSSHNL ISELPDHLGQ
SLLMLKHFNL SGNKISFLQR GSLPASLEEL DISDNAITTI VQDTFGQLTS LSVLTVQGKH
FFCNCDLYWF VNIYIRNPHL QINGKDDLRC SFPPDRRGSL VKSSNLTLLH CSLGIQMAIT
ACMAILVVLV LTGLCWRFDG LWYVRMGWYW CMAKRRQYKK RPENKPFDAF ISYSEHDADW
TKEHLLKKLE TDGFKICYHE RDFKPGHPVL GNIFYCIENS HKVLFVLSPS FVNSCWCQYE
LYFAEHRVLD ENQDSLIMVV LEDLPPDSVP QKFSKLRKLL KRKTYLKWSP EEHKQKIFWH
QLAAVLKTTN EPLVRAENGP NEDVIEME
//
