ID C4PBX0_CHICK Unreviewed; 652 AA.
AC C4PBX0;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=TLR1LB {ECO:0000313|EMBL:ACR26467.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ACR26467.1};
RN [1] {ECO:0000313|EMBL:ACR26467.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=659 {ECO:0000313|EMBL:ACR26467.1};
RX PubMed=20483729; DOI=10.4049/jimmunol.0903092;
RA Downing T., Lloyd A.T., O'Farrelly C., Bradley D.G.;
RT "The differential evolutionary dynamics of avian cytokine and TLR gene
RT classes.";
RL J. Immunol. 184:6993-7000(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; FJ915304; ACR26467.1; -; Genomic_DNA.
DR AlphaFoldDB; C4PBX0; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 440..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 494..637
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 652 AA; 75224 MW; 0A7482605A66822D CRC64;
MTKNMRYLRN CFIYNCLFVF TFWDNIGLAK KNELFASVPN NFLEDGLDKK NMSFPHSYAN
NQHYKADYGW VVIENTTESL SLSEIADDNV RKLITLLSKL RKGSRLQNLT LTNMSVDWKN
IIKVLQVVWH SSIEYFNINN LTQLGNVVST RFDYSKTSMK AFAVNKVLIT DLYFSQDDIY
NIFANMNIAA LTIAESELIH MLCPSSDSPL RYINFSKNDL TDLLFQNCDK LIQLEKFILH
RNKFESLSKV SFMTSRMKSL RYLDMSSNLL RNSRAEGRCQ WADSLAELDL SSNQLTEAVF
ECLPANINKV DLQNNQIASV PKGITELHSL QELNLASNRL ADLPGCRAFT GLEILNIERN
LILTPSADFF ETCPSVKELQ AGQNPFKCSC ELQDFLRLER QSGGKLSGWP EAYVCKYPED
LSGTQLKDFH LTELACNTTL LLVTALLLTL VLVAVVAFPC IYLDVPWYVR MLWQWTQTKR
RAWHDCPEER ETALQFHAFI SYSERDSLWV KNELIPNLEK GEGCIQLCQH ERNFIPGKSI
VENIINCIEK SYKSIFVLSP NFVQSEWCHY ELYFAHHKLF SENSNSLILI LLEPIPPYVI
PARYHKLKAL MAKRTYLEWP KERSKHALFW ANLRAAISIN LSVADEQNRT EV
//
