ID C4PCB2_CHICK Unreviewed; 840 AA.
AC C4PCB2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=TLR3 {ECO:0000313|EMBL:ACR26337.1};
DE Flags: Fragment;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ACR26337.1};
RN [1] {ECO:0000313|EMBL:ACR26337.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=719 {ECO:0000313|EMBL:ACR26337.1};
RX PubMed=20483729; DOI=10.4049/jimmunol.0903092;
RA Downing T., Lloyd A.T., O'Farrelly C., Bradley D.G.;
RT "The differential evolutionary dynamics of avian cytokine and TLR gene
RT classes.";
RL J. Immunol. 184:6993-7000(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; FJ915446; ACR26337.1; -; Genomic_DNA.
DR AlphaFoldDB; C4PCB2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF549; TOLL-LIKE RECEPTOR 13; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 7.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 641..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 691..835
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 840
FT /evidence="ECO:0000313|EMBL:ACR26337.1"
SQ SEQUENCE 840 AA; 96208 MW; 15F7581F93A55141 CRC64;
MLEEVKLAEL KKLVPENLTE YSNLIYLNAG YNIISKLQPG LCKSLPLLQI LKLEHNQLHE
LPDGVFASCS NLTELNLGYN IIEVKNDPFK TLENLNILDL SHNHLKSANL GLQQQLKNLR
ELVLYSNQIT ELNKEDLKFL SNTSLNSLDL SSNPLKEFHT GCLHAIGNLF GLILNNVELG
ENRTKKLCTE LSDTAIQNLS LSHVKLSHIN RLTLQGLQGT NLTVLNLSKN SLSVIEDDSF
QWLSKLEYLN LEDNNIINVS SHLFYGLSSI THLNLINSLT GKIEDFSFQW LHHLEFLIMD
NNNFPRITTN MFTGLKNLKY LSLYNCNTNL QRITNKTFVS LANSSLQVLN LTKTRISTVE
SGAFSSLGQL KILDLGLNEI NQELTGHEFE GLNNIEYIYL SYNKNVTLRS ESFIFVPSLR
KLMLRKVGCN NLAISPSPFH PLRNLTVLDI SNNNIANIKE DLFNGLHELD ILNLQHNNLA
RLWKCANPGG PVLFLKDVPN LHILNLKSNG FDEIPVHVFK GLHQLKDLDL GSNNLNLLPV
TLFDDQTSLN TLNLQKNLIT SVEENVFGPA FKSLRTLEMD FNPFDCTCES IAWFASWLND
TQAYIPGLQS QYICNTPPKY HGTLVLHFDT SACKDSAPFK LLFLITTTAV MQFMFIVLLI
HFEGWRIAFY WNISINRILG FKELDRLPGV FDYDAYVIHA RKDTNWVLTN FTTLEENEQF
QVKFCLEERD FEAGISEFEA IINCIRRSRK IIFIVTEHLL QDPWCRKFKV HHALQQAIEQ
SRDSIILIFL HNIQDYKLNH ALCLRRGMFR SCCILNWPVQ KERINAFHQQ LMMALKSNSK
//
