ID C4QV71_KOMPG Unreviewed; 74 AA.
AC C4QV71;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN OrderedLocusNames=PAS_chr1-3_0087 {ECO:0000313|EMBL:CAY67144.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY67144.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY67144.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the ATX1 family.
CC {ECO:0000256|ARBA:ARBA00038171}.
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DR EMBL; FN392319; CAY67144.1; -; Genomic_DNA.
DR RefSeq; XP_002489425.1; XM_002489380.1.
DR AlphaFoldDB; C4QV71; -.
DR SMR; C4QV71; -.
DR STRING; 644223.C4QV71; -.
DR EnsemblFungi; CAY67144; CAY67144; PAS_chr1-3_0087.
DR GeneID; 8197397; -.
DR KEGG; ppa:PAS_chr1-3_0087; -.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_134973_3_1_1; -.
DR InParanoid; C4QV71; -.
DR OMA; MTHTYKF; -.
DR OrthoDB; 1107952at2759; -.
DR Proteomes; UP000000314; Chromosome 1.
DR GO; GO:0016531; F:copper chaperone activity; IEA:EnsemblFungi.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR46365; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR PANTHER; PTHR46365:SF1; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..68
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 74 AA; 8000 MW; D10DA9E601B9F269 CRC64;
MSDHKYHFDV KMSCSGCSNA VNRVLNKLDG VKNVDISLEK QTVDVVTSNA LGYDTVLQTI
SKTGKQVIGG NVVE
//
