ID   C4QXF7_KOMPG            Unreviewed;       470 AA.
AC   C4QXF7;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   28-JUN-2023, entry version 72.
DE   RecName: Full=Enhancer of mRNA-decapping protein 3 {ECO:0000256|ARBA:ARBA00015797};
GN   OrderedLocusNames=PAS_chr1-4_0100 {ECO:0000313|EMBL:CAY67930.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY67930.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY67930.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC       {ECO:0000256|ARBA:ARBA00004201}.
CC   -!- SIMILARITY: Belongs to the EDC3 family.
CC       {ECO:0000256|ARBA:ARBA00006610}.
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DR   EMBL; FN392319; CAY67930.1; -; Genomic_DNA.
DR   RefSeq; XP_002490211.1; XM_002490166.1.
DR   AlphaFoldDB; C4QXF7; -.
DR   SMR; C4QXF7; -.
DR   STRING; 644223.C4QXF7; -.
DR   EnsemblFungi; CAY67930; CAY67930; PAS_chr1-4_0100.
DR   GeneID; 8197317; -.
DR   KEGG; ppa:PAS_chr1-4_0100; -.
DR   eggNOG; KOG2585; Eukaryota.
DR   HOGENOM; CLU_037134_0_0_1; -.
DR   InParanoid; C4QXF7; -.
DR   OMA; KNRDDEC; -.
DR   OrthoDB; 1409462at2759; -.
DR   Proteomes; UP000000314; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:EnsemblFungi.
DR   GO; GO:0033962; P:P-body assembly; IEA:EnsemblFungi.
DR   GO; GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IEA:EnsemblFungi.
DR   CDD; cd00600; Sm_like; 1.
DR   Gene3D; 3.40.50.10260; YjeF N-terminal domain; 1.
DR   InterPro; IPR025762; DFDF.
DR   InterPro; IPR019050; FDF_dom.
DR   InterPro; IPR047575; Sm.
DR   InterPro; IPR004443; YjeF_N_dom.
DR   InterPro; IPR036652; YjeF_N_dom_sf.
DR   PANTHER; PTHR13612:SF0; ENHANCER OF MRNA-DECAPPING PROTEIN 3; 1.
DR   PANTHER; PTHR13612; UNCHARACTERIZED; 1.
DR   Pfam; PF09532; FDF; 1.
DR   Pfam; PF03853; YjeF_N; 1.
DR   SMART; SM01199; FDF; 1.
DR   SUPFAM; SSF64153; YjeF N-terminal domain-like; 1.
DR   PROSITE; PS51512; DFDF; 1.
DR   PROSITE; PS52002; SM; 1.
DR   PROSITE; PS51385; YJEF_N; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT   DOMAIN          1..66
FT                   /note="Sm"
FT                   /evidence="ECO:0000259|PROSITE:PS52002"
FT   DOMAIN          93..129
FT                   /note="DFDF"
FT                   /evidence="ECO:0000259|PROSITE:PS51512"
FT   DOMAIN          211..444
FT                   /note="YjeF N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51385"
FT   REGION          74..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          161..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   470 AA;  52558 MW;  C4903124AD806899 CRC64;
     MSQFLGSTVL LVLKNNKRFQ GKIDAVDNKV ASLSSVVDLN TETRQSIPDQ KIPGRDIAKL
     EVLSLCDKVL KNNESKKNKN KKKSKAKKDD NDIAWNGDDK LNEEFDFQSN LDKFDKESVF
     RELSAKDNID PNLRLAGHNK KVNYDHNEMV VKKEVDTWDN QQSIPTPIAP SRSSTSTFPH
     LQRQPSIRQP GFGIQLTDGA NLLPSCSPVQ LLEMERITVD EYKVPIEMLL ENVAINVSSI
     VIKSLGGYAR FDQTNHNLPP LILFLVGNNR SGARVLSVGR RLVNIGARCV AILTNTNSDE
     LIDSVKRQST IFTKFGGRLV YDINQLTVLL DSLQSPLEFV VDGLQGYDNH LDDLFGVELT
     TSNSLIEWVN QQYVNVLSLD IPSGLEPSSA HINSENAFLQ SKFIVSVGLP LNGVLNAYKE
     GGVLTPGDCI HYLVDLSVPR AIFKKGSLRK FDRDWFEDKG FIELFIKQTI
//