ID C4QZP8_KOMPG Unreviewed; 475 AA.
AC C4QZP8;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mut {ECO:0000313|EMBL:CAY68722.1};
GN OrderedLocusNames=PAS_chr2-1_0118 {ECO:0000313|EMBL:CAY68722.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY68722.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY68722.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
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DR EMBL; FN392320; CAY68722.1; -; Genomic_DNA.
DR RefSeq; XP_002491002.1; XM_002490957.1.
DR AlphaFoldDB; C4QZP8; -.
DR STRING; 644223.C4QZP8; -.
DR EnsemblFungi; CAY68722; CAY68722; PAS_chr2-1_0118.
DR GeneID; 8198514; -.
DR KEGG; ppa:PAS_chr2-1_0118; -.
DR eggNOG; KOG2710; Eukaryota.
DR HOGENOM; CLU_016108_1_0_1; -.
DR InParanoid; C4QZP8; -.
DR OMA; HCAIEEY; -.
DR OrthoDB; 25175at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR PANTHER; PTHR15228:SF25; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 109..384
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 27..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 54405 MW; 02B36148425E1180 CRC64;
METSTSPPRN SISSWWSNFK QRHSSNESLS IYTSNETPSK QGGTTNTSPK RPQMRPKSRS
SNYIPYRLSL HRNSKELDLS DEAKLKQHRN SFLNSRQQDF FEDSQVFAVP LKQSLEIASA
KINCGSSDYG LIPVVIAQCG IYIKKNGLDV EGIFRVAGSS RRVKELQFVF STAPLYGRKI
DWESYGTTVH DAASLMRRYL NFLPEPLVSL ALYEQFRDPI RSRPRILNYL KNKSEKKDKE
KSPEQEGEKD QQDREQTGVQ AQSEQESKQQ AKDIDEQNEE YKAKEAKKAA NEKKLKKSIL
AALKEYALLF NYLPKESRHL ILYILDLLSL CTQHRDKNLM TAKNLAAVFQ PSILTHPDHD
MSPEEYALSH AVLEIWIEFS YILIARLNDS PQEIIRLTDT KGTKRDTIPS VTTSTDSTFL
APPPGQHRRQ HSRSLSSVVP VNDRIYQNKQ KPQLLDDQLQ ETTPEPQNDK ESDDV
//
