ID C4R1A0_KOMPG Unreviewed; 629 AA.
AC C4R1A0;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 08-NOV-2023, entry version 82.
DE SubName: Full=Fimbrin, actin-bundling protein {ECO:0000313|EMBL:CAY69274.1};
GN OrderedLocusNames=PAS_chr2-1_0631 {ECO:0000313|EMBL:CAY69274.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY69274.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY69274.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
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DR EMBL; FN392320; CAY69274.1; -; Genomic_DNA.
DR RefSeq; XP_002491554.1; XM_002491509.1.
DR AlphaFoldDB; C4R1A0; -.
DR SMR; C4R1A0; -.
DR STRING; 644223.C4R1A0; -.
DR EnsemblFungi; CAY69274; CAY69274; PAS_chr2-1_0631.
DR GeneID; 8199245; -.
DR KEGG; ppa:PAS_chr2-1_0631; -.
DR eggNOG; KOG0046; Eukaryota.
DR HOGENOM; CLU_015284_3_0_1; -.
DR InParanoid; C4R1A0; -.
DR OMA; WQLMRKN; -.
DR OrthoDB; 5475188at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0099079; C:actin body; IEA:EnsemblFungi.
DR GO; GO:0030479; C:actin cortical patch; IEA:EnsemblFungi.
DR GO; GO:0032432; C:actin filament bundle; IEA:EnsemblFungi.
DR GO; GO:0031097; C:medial cortex; IEA:EnsemblFungi.
DR GO; GO:0120106; C:mitotic actomyosin contractile ring, distal actin filament layer; IEA:EnsemblFungi.
DR GO; GO:0051015; F:actin filament binding; IEA:EnsemblFungi.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:EnsemblFungi.
DR GO; GO:0051666; P:actin cortical patch localization; IEA:EnsemblFungi.
DR GO; GO:0044396; P:actin cortical patch organization; IEA:EnsemblFungi.
DR GO; GO:0044837; P:actomyosin contractile ring organization; IEA:EnsemblFungi.
DR GO; GO:0006897; P:endocytosis; IEA:EnsemblFungi.
DR GO; GO:0070649; P:formin-nucleated actin cable assembly; IEA:EnsemblFungi.
DR CDD; cd21294; CH_FIMB_rpt1; 1.
DR CDD; cd21300; CH_FIMB_rpt3; 1.
DR CDD; cd21303; CH_FIMB_rpt4; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961:SF18; FI19014P1; 1.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR Pfam; PF00307; CH; 4.
DR SMART; SM00033; CH; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 2.
DR PROSITE; PS50021; CH; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 51..86
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 127..247
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 275..378
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 399..508
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 521..629
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 629 AA; 70222 MW; C605F3FC8CAA829D CRC64;
MSVLKLQKKY PVLTQEDLFQ VIDDFRKIDL DDKGWADKQE VIESVSNAGH GSYDEIRETL
KTVSVDASGH VELEDFVELV SKLKESKVNP KQPTRTDTSD IFHRGAKAST KHVFKGASSG
STHTINDEER VEFTRHINSV LAGDPDIGDR LPFPTDSNQI FDECSDGLVL SKLINDSVPD
TIDTRVLNFP KGNKKLNNFT MSENANIVIN SAKAIGCVVV NVHSEDIIDG REHLILGIIW
QIIRRGLLSK IDIKLHPELY RLLEDDETLE QFLRLPPEQI LLRWVNYHLK AAGTSRRISN
FSKDVSDGEA YTYLLNQLQP QHCDLSPLKT SDLLTRASQI LDSADRIGVR KYLTPTSLVA
GNPKLNLAFV AHLFNTYPGL DPIEEEEKAE IEEFDAEGER EARVFTLWLN SLDVDPPIVN
LFEDLKDGTI LLQAFDKVMP GSVSLNHVNK RKNGVELSRF KALENTNYAV EIGKANNFSL
VGIEGADIVD GTKTLTLGLV WQLMRRNINN TLSSLSVNGK EISDREILQW ANAQVAKGGK
SSQIRSFKEP SLSSGIFLLD VLHGLKPGYV DYDLVTAGST EEDRYANAKL AISIARKLGA
LIWLVPEDIN EVRPRLILTF IGSLMALEL
//
