ID   C4R4Y2_KOMPG            Unreviewed;       308 AA.
AC   C4R4Y2;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Cardiolipin synthase {ECO:0000313|EMBL:CAY70618.1};
GN   OrderedLocusNames=PAS_chr3_0570 {ECO:0000313|EMBL:CAY70618.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70618.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY70618.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000256|RuleBase:RU003750}.
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DR   EMBL; FN392321; CAY70618.1; -; Genomic_DNA.
DR   RefSeq; XP_002492797.1; XM_002492752.1.
DR   AlphaFoldDB; C4R4Y2; -.
DR   STRING; 644223.C4R4Y2; -.
DR   EnsemblFungi; CAY70618; CAY70618; PAS_chr3_0570.
DR   GeneID; 8199934; -.
DR   KEGG; ppa:PAS_chr3_0570; -.
DR   eggNOG; KOG1617; Eukaryota.
DR   HOGENOM; CLU_051314_0_0_1; -.
DR   InParanoid; C4R4Y2; -.
DR   OMA; KRFNMAS; -.
DR   OrthoDB; 5490365at2759; -.
DR   Proteomes; UP000000314; Chromosome 3.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0043337; F:cardiolipin synthase (CMP-forming); IEA:EnsemblFungi.
DR   GO; GO:0006873; P:intracellular monoatomic ion homeostasis; IEA:EnsemblFungi.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0007006; P:mitochondrial membrane organization; IEA:EnsemblFungi.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006612; P:protein targeting to membrane; IEA:EnsemblFungi.
DR   Gene3D; 1.20.120.1760; -; 1.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR   InterPro; IPR048254; CDP_ALCOHOL_P_TRANSF_CS.
DR   PANTHER; PTHR14269:SF60; CARDIOLIPIN SYNTHASE (CMP-FORMING); 1.
DR   PANTHER; PTHR14269; CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003750};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        186..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   308 AA;  34357 MW;  B97B18C4E1BD2A4E CRC64;
     MYFGGAVRRV AFVSGGPFHH LTMPTLRALP PLAVVNLLSV RHLTNKSPQR KQTMITKTKE
     IGKKMSIETV ETTKKIKENT LAKSKELKES FSSMIPSEYH ENIYTIPNIL TFTRLLSAPI
     IGYLIVHNHV TSALSLFTYS CITDFIDGYI ARKYNMKSVV GTVIDPMADK SLMIICTACM
     AQSHQIPMYV AVIILGRDVL LGLSAIYYRY VSLPRPKTFK RFWDFSIPSA EVRPTTISKI
     NTGLQMVYIG SSMIKPVLIP YLTSDSSAMV LQGLFALEIT VAISTILSGL SYVFSKDAVR
     ILNKENAK
//