ID C4R4Z2_KOMPG Unreviewed; 348 AA.
AC C4R4Z2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=3'-5' exoribonuclease involved in rRNA processing {ECO:0000313|EMBL:CAY70628.1};
GN OrderedLocusNames=PAS_chr3_0581 {ECO:0000313|EMBL:CAY70628.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70628.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70628.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the RRP4 family.
CC {ECO:0000256|ARBA:ARBA00009155}.
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DR EMBL; FN392321; CAY70628.1; -; Genomic_DNA.
DR RefSeq; XP_002492807.1; XM_002492762.1.
DR AlphaFoldDB; C4R4Z2; -.
DR SMR; C4R4Z2; -.
DR STRING; 644223.C4R4Z2; -.
DR EnsemblFungi; CAY70628; CAY70628; PAS_chr3_0581.
DR GeneID; 8199785; -.
DR KEGG; ppa:PAS_chr3_0581; -.
DR eggNOG; KOG3013; Eukaryota.
DR HOGENOM; CLU_034114_3_0_1; -.
DR InParanoid; C4R4Z2; -.
DR OMA; GVNGFIW; -.
DR OrthoDB; 5472588at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd22525; KH-I_Rrp4_eukar; 1.
DR CDD; cd05789; S1_Rrp4; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR025721; Exosome_cplx_N_dom.
DR InterPro; IPR026699; Exosome_RNA_bind1/RRP40/RRP4.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR048565; RRP4_S1.
DR PANTHER; PTHR21321:SF4; EXOSOME COMPLEX COMPONENT RRP4; 1.
DR PANTHER; PTHR21321; PNAS-3 RELATED; 1.
DR Pfam; PF14382; ECR1_N; 1.
DR Pfam; PF15985; KH_6; 1.
DR Pfam; PF21266; RRP4_S1; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF110324; Ribosomal L27 protein-like; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 40..77
FT /note="Exosome complex component N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14382"
FT DOMAIN 89..161
FT /note="RRP4 S1"
FT /evidence="ECO:0000259|Pfam:PF21266"
FT DOMAIN 183..222
FT /note="K Homology"
FT /evidence="ECO:0000259|Pfam:PF15985"
SQ SEQUENCE 348 AA; 38363 MW; AB196DB8107A08E3 CRC64;
MTEIISIRKP LNPNADSDVE SSDEEMLEAS LAPKNNNQSI VTPGELITED PIWMRGHGTY
YLNEKTYSSV AGTISKVNKL LSVVPLRGRY QPETGDHVVG RITEVGPKRW KVDIGARQDA
ALMLGSVNLP GGVLRRKSES DELQMRNFLK EGDLLNAEVQ SIFQDGSASL HTRSLKYGKL
RNGYFVKVPS SLIIRQKNHL HELPGSITII IGVNGYIWIS KTLYQHQKSL PSTTGNNALD
STVSSAAAKS NSYTPGQGSV SITRLEEESS WEIYSDKNEP ISVATKDTIA RYANCVKALA
KCDIGITETR IIAAYEASMV YENAGLLLDE ETMKSIGEDV LNRERMRG
//
