ID C4R5J9_KOMPG Unreviewed; 703 AA.
AC C4R5J9;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Glycogen [starch] synthase {ECO:0000256|RuleBase:RU363104};
DE EC=2.4.1.11 {ECO:0000256|RuleBase:RU363104};
GN OrderedLocusNames=PAS_chr3_0781 {ECO:0000313|EMBL:CAY70835.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70835.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70835.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-
CC reducing end of alpha-1,4-glucan. {ECO:0000256|RuleBase:RU363104}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:18549, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00043769};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18550;
CC Evidence={ECO:0000256|ARBA:ARBA00043769};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004964, ECO:0000256|RuleBase:RU363104}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 3 family.
CC {ECO:0000256|ARBA:ARBA00010686, ECO:0000256|RuleBase:RU363104}.
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DR EMBL; FN392321; CAY70835.1; -; Genomic_DNA.
DR RefSeq; XP_002493014.1; XM_002492969.1.
DR AlphaFoldDB; C4R5J9; -.
DR SMR; C4R5J9; -.
DR STRING; 644223.C4R5J9; -.
DR CAZy; GT3; Glycosyltransferase Family 3.
DR EnsemblFungi; CAY70835; CAY70835; PAS_chr3_0781.
DR GeneID; 8200474; -.
DR KEGG; ppa:PAS_chr3_0781; -.
DR eggNOG; KOG3742; Eukaryota.
DR HOGENOM; CLU_015910_1_0_1; -.
DR InParanoid; C4R5J9; -.
DR OMA; RDVRNHI; -.
DR OrthoDB; 9432at2759; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR008631; Glycogen_synth.
DR PANTHER; PTHR10176:SF3; GLYCOGEN [STARCH] SYNTHASE; 1.
DR PANTHER; PTHR10176; GLYCOGEN SYNTHASE; 1.
DR Pfam; PF05693; Glycogen_syn; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 2.
PE 3: Inferred from homology;
KW Glycogen biosynthesis {ECO:0000256|ARBA:ARBA00023056,
KW ECO:0000256|RuleBase:RU363104};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363104};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363104}.
FT REGION 612..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 79804 MW; 2C7B456D10EA6B56 CRC64;
MGKDITNHLL FEIATEVANR VGGIYSVLKS KAPVTVAEYK DRYTLIGPLN ANSANVEVEE
LPVLDPVLKR TLDSMSGRGI RYLYGRWLIE GAPRVILFDI GSAAGYLNEW KSDLWNIAGV
PTPEHDVETN DAILLGYLVA WFLGELVHND GHKRAIICHA HEWLAAVCLP LCRKRKIDVT
TVFTTHATLL GRYLCAGSVD FYNNLDKFDV DAEAGKRGIY HRYCIERAAA HSADVFTTVS
HITAYEAEHL LKRKPDGVLP NGLNVIKFQA VHEFQNLHAE KKEKINEFIR GHFYGQLDFK
LNNTLYFFIA GRYEYRNKGV DFFIESLARL NHRLKASNSN MTVVAFIIMP AKTNSYTVET
LKGQAVIKQL ENTINDIEAL VGKRLFEFCQ HPATSSNSSH IEMPDIDDLL KPSDRVLLKR
RMFAMKREGL PPIVTHNMAD DSTDPILNQI RNVQLFNRPE DRVKIIFHPE FLNSNNPILS
LDYDEFVRGC HLGVFPSYYE PWGYTPAECT VMGIPSITTN LSGFGCYMED LIENSSDYGI
YIVDRRLKSV DESIDQLTSY MFDFVDKTRR QRINQRNRVE RLSDLLDWRR MGLEYVKGRS
LALRRAYPDE FKNQNNEHSN PFSESNSIKI TRPLSVPGSP RDKYSSSANI MTPGDLGTLQ
ENNSTDYISW RLGNDTEEDG LDVTLRGLSV APSAEQSGDE FDA
//
