ID C4R600_KOMPG Unreviewed; 165 AA.
AC C4R600;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Ribonuclease P/MRP protein subunit POP5 {ECO:0000256|PIRNR:PIRNR023803};
DE EC=3.1.26.5 {ECO:0000256|PIRNR:PIRNR023803};
GN OrderedLocusNames=PAS_chr3_0927 {ECO:0000313|EMBL:CAY70986.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70986.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70986.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- FUNCTION: Component of ribonuclease P, a protein complex that generates
CC mature tRNA molecules by cleaving their 5'-ends.
CC {ECO:0000256|PIRNR:PIRNR023803}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC from tRNA precursor.; EC=3.1.26.5;
CC Evidence={ECO:0000256|PIRNR:PIRNR023803};
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC component 2 family. {ECO:0000256|ARBA:ARBA00010800,
CC ECO:0000256|PIRNR:PIRNR023803}.
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DR EMBL; FN392321; CAY70986.1; -; Genomic_DNA.
DR RefSeq; XP_002493165.1; XM_002493120.1.
DR AlphaFoldDB; C4R600; -.
DR SMR; C4R600; -.
DR STRING; 644223.C4R600; -.
DR EnsemblFungi; CAY70986; CAY70986; PAS_chr3_0927.
DR GeneID; 8199677; -.
DR KEGG; ppa:PAS_chr3_0927; -.
DR eggNOG; KOG4639; Eukaryota.
DR HOGENOM; CLU_086710_1_2_1; -.
DR InParanoid; C4R600; -.
DR OMA; IVRCPRA; -.
DR OrthoDB; 2787248at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0005655; C:nucleolar ribonuclease P complex; IEA:EnsemblFungi.
DR GO; GO:0000172; C:ribonuclease MRP complex; IEA:EnsemblFungi.
DR GO; GO:0000171; F:ribonuclease MRP activity; IEA:EnsemblFungi.
DR GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR GO; GO:0033204; F:ribonuclease P RNA binding; IEA:InterPro.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0034965; P:intronic box C/D RNA processing; IEA:EnsemblFungi.
DR GO; GO:0000294; P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent; IEA:EnsemblFungi.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IEA:EnsemblFungi.
DR Gene3D; 3.30.70.3250; Ribonuclease P, Pop5 subunit; 1.
DR HAMAP; MF_00755; RNase_P_2; 1.
DR InterPro; IPR002759; Pop5/Rpp14/Rnp2-like.
DR InterPro; IPR016819; RNase_P/MRP_POP5.
DR InterPro; IPR038085; Rnp2-like_sf.
DR PANTHER; PTHR15441; RIBONUCLEASE P PROTEIN SUBUNIT P14; 1.
DR PANTHER; PTHR15441:SF2; RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5; 1.
DR Pfam; PF01900; RNase_P_Rpp14; 1.
DR PIRSF; PIRSF023803; Ribonuclease_P_prd; 1.
DR SUPFAM; SSF160350; Rnp2-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694,
KW ECO:0000256|PIRNR:PIRNR023803}.
SQ SEQUENCE 165 AA; 18716 MW; 877EC92724B46DC3 CRC64;
MVRLKNRYIL FDILYPQEID DFSRSKALVA MHKSTSSQVN PQTILIALRN SLKQNFGDHI
AGIAGSTAQT KYFSNKTSTG IIRCPRDSFR YTCAALSLIT HLEGQRILIR IVRISGTIRT
CERYAVKKNK ETLTLLHKDH NNVLDLVFGG NQKIPSFDTD NDDDE
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