ID C4R6B2_KOMPG Unreviewed; 1044 AA.
AC C4R6B2;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Component of the Paf1p complex {ECO:0000313|EMBL:CAY71098.1};
GN OrderedLocusNames=PAS_chr3_1035 {ECO:0000313|EMBL:CAY71098.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY71098.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY71098.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
RN [2] {ECO:0007829|PDB:7XN7, ECO:0007829|PDB:7XSE}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS).
RX PubMed=35981082; DOI=10.1126/science.abp9466;
RA Ehara H., Kujirai T., Shirouzu M., Kurumizaka H., Sekine S.I.;
RT "Structural basis of nucleosome disassembly and reassembly by RNAPII
RT elongation complex with FACT.";
RL Science 377:eabp9466-eabp9466(2022).
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DR EMBL; FN392321; CAY71098.1; -; Genomic_DNA.
DR RefSeq; XP_002493277.1; XM_002493232.1.
DR PDB; 7XN7; EM; 3.10 A; q=1-1044.
DR PDB; 7XSE; EM; 3.60 A; q=1-1044.
DR PDB; 7XSX; EM; 3.80 A; q=1-1044.
DR PDB; 7XSZ; EM; 3.40 A; q=1-1044.
DR PDB; 7XT7; EM; 4.20 A; q=1-1044.
DR PDB; 7XTD; EM; 3.90 A; q=1-1044.
DR PDB; 7XTI; EM; 3.90 A; q=1-1044.
DR AlphaFoldDB; C4R6B2; -.
DR EMDB; EMD-33313; -.
DR EMDB; EMD-33424; -.
DR EMDB; EMD-33436; -.
DR EMDB; EMD-33437; -.
DR EMDB; EMD-33441; -.
DR EMDB; EMD-33447; -.
DR EMDB; EMD-33450; -.
DR SMR; C4R6B2; -.
DR STRING; 644223.C4R6B2; -.
DR EnsemblFungi; CAY71098; CAY71098; PAS_chr3_1035.
DR GeneID; 8199997; -.
DR KEGG; ppa:PAS_chr3_1035; -.
DR eggNOG; KOG2002; Eukaryota.
DR HOGENOM; CLU_003008_0_1_1; -.
DR InParanoid; C4R6B2; -.
DR OMA; EHWLTIA; -.
DR OrthoDB; 3573659at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR031101; Ctr9.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14027; RNA POLYMERASE-ASSOCIATED PROTEIN CTR9; 1.
DR PANTHER; PTHR14027:SF2; RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG; 1.
DR Pfam; PF13432; TPR_16; 2.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 4.
DR PROSITE; PS50005; TPR; 2.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7XN7, ECO:0007829|PDB:7XSE};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 179..212
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 746..779
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 936..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 884..921
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 936..950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..997
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1044
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 120142 MW; ECC6B7376B84C0F0 CRC64;
MSLLDQDYYL SALPEDKRAE LVTLQLTIPL KSGDEVVTID FNEDVDVSQL CVLLESENAR
PDLWLSAAKV FVSKGNIAGS QEIIRKALQS NVILDSSASV TSLFHNFSFW LSLMEYVSTN
SREDQFLEYA SNSLQASNSL DSGLILNGIG NGVLYAKSRR YDEALKEFDN LLKKKSTNIL
AILGKAQILY KRQKYSQALE LYQKALTINP LIVPDPRLGI GLCFWHLNNK QLAEQAWHNS
LKVHPQNNLN TKILICLAKF DYCFNESKDD DEFTALYRES LEFLHSCLKE DAKHPLLLMV
LASYYFSKED YEKVEKLCNL VLKENSRNAA FVSASHFWLA RVAYHKEDYV QAQKQFKQAE
DSQNSNTLAK LGYAQCLIAR NEVGDATIYL EKFFKENQDS KSSEMMLLLG IIYSQSGKSY
YKAIIFLEKY VAVCQEENYP ILPEAYLVLS RVYENKDLNV ALDYLMKAND ILGDKANVYV
LNNLGIYHFF RNNVSQSSDF FAQSLEALNN VSPQNKEALS ITLHYNKARV EEVSNQSEAE
KLYSKLMEKC PGYTSNKIRY IYLLALKSNG NNYADVQQLL DDFPSDLEVR SFYGWFLKRY
GRKNGLKQDL ESQHHKDTLI NYDKHDCYAL LSLGNIYATI AREMKVTDQK QNEIKRQQYL
RAAQFYHKVL SIDPKNIYAA QGIAIIFSDK ERTGLALEIF KKVRDTVQDL GTFINLGHCF
MEAKQFGKAI ESYTIALEKF SNGMDSKLLV LIGRAWYHRG FYEKSMDAYK KALEVSEQAY
QLSKLPALRF NIVFIQFQIA DFVKSLPNTQ RDLTTLENAL SGLNDAIKSL LKLAELEQPP
YPSEDLKARA TMGSNTLRNQ LERAIQDQQD YEMSIQEKLR TARRKQQLDE EKRLEQEQRR
LEEARKRQEA ELIKRQELIK QAEEWNKMDI DAAKDNNDVL SEDGGEGEKK TTKKRKRKQK
VSEDIAPDLD RINEENGNTE DYDPILDNEE EENYDEKDSE NKENGQNGQN EEVYPESEGD
DEDDVTNTKR QKRSKGIVDE EDSE
//
