ID C4R878_KOMPG Unreviewed; 377 AA.
AC C4R878;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAY71803.1};
GN OrderedLocusNames=PAS_chr4_0543 {ECO:0000313|EMBL:CAY71803.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY71803.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY71803.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; FN392322; CAY71803.1; -; Genomic_DNA.
DR RefSeq; XP_002493982.1; XM_002493937.1.
DR AlphaFoldDB; C4R878; -.
DR SMR; C4R878; -.
DR STRING; 644223.C4R878; -.
DR EnsemblFungi; CAY71803; CAY71803; PAS_chr4_0543.
DR GeneID; 8200811; -.
DR KEGG; ppa:PAS_chr4_0543; -.
DR eggNOG; KOG2743; Eukaryota.
DR HOGENOM; CLU_017452_6_0_1; -.
DR InParanoid; C4R878; -.
DR OMA; GHSHMDP; -.
DR OrthoDB; 1010489at2759; -.
DR Proteomes; UP000000314; Chromosome 4.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR GO; GO:0140827; F:zinc chaperone activity; IEA:EnsemblFungi.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF31; COBW DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 41..237
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT DOMAIN 291..374
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07683"
SQ SEQUENCE 377 AA; 41529 MW; F4906C4E447193EF CRC64;
MDEDIPQLVE DVSEIKGELI VDPSNPVSVI RNAVDESVKV PISIITGYLG SGKSTLLKSI
AEKGDRKLAV ILNEFGDSVE IEKSLTIQDK GESYEEWLDL GNGCLCCSVK DNGVAAIERL
IAKKAGFDYI LLETTGVADP GPIVNMFWVD DGLASNVYID GVVCVLDSEH VESCLDDVGG
HWHGEDISTE TDGTTTAHLQ IALADVILLN KRDRINEQDE ARIKKRIKTI NSIAPIYETQ
FGDIDLSKIL DLHAYENRDI ESIQSIKPSF HDSRISTICI DLPLFDFTSL QKFEHILQEA
LWEGSFGSLE VDIHRTKALL AFPDGFKVVQ GVRQTYDIID SPNTGSSSPY TTGKLVLIGK
NLDQERIANH INSILSN
//
