ID C4R8L6_KOMPG Unreviewed; 636 AA.
AC C4R8L6;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=GTPase-activating protein (RhoGAP) for Rho3p and Rho4p {ECO:0000313|EMBL:CAY71941.1};
GN OrderedLocusNames=PAS_chr4_0681 {ECO:0000313|EMBL:CAY71941.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY71941.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY71941.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
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DR EMBL; FN392322; CAY71941.1; -; Genomic_DNA.
DR RefSeq; XP_002494120.1; XM_002494075.1.
DR AlphaFoldDB; C4R8L6; -.
DR SMR; C4R8L6; -.
DR STRING; 644223.C4R8L6; -.
DR EnsemblFungi; CAY71941; CAY71941; PAS_chr4_0681.
DR GeneID; 8201388; -.
DR KEGG; ppa:PAS_chr4_0681; -.
DR eggNOG; KOG1450; Eukaryota.
DR HOGENOM; CLU_010730_2_0_1; -.
DR InParanoid; C4R8L6; -.
DR OMA; DSGWQAR; -.
DR OrthoDB; 5482027at2759; -.
DR Proteomes; UP000000314; Chromosome 4.
DR GO; GO:0005933; C:cellular bud; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07652; F-BAR_Rgd1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF136; RHO GTPASE-ACTIVATING PROTEIN RGD1; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 51..321
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 438..632
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 70600 MW; 8C12CDD4AA79AB8A CRC64;
MDSRDKSIDQ STSEATDPNT SLGTVDQELE AVSSPTTPAK VESSASLLED PQIAKILQSD
SAMDILLDRL KRSITTCDEF SRYIKKKSIL EDDHYTQLRK ISKHTQDTLK NDGKKFKTDS
FERSFEKIVS FDSELFNVGS PYVKALTLMY EQLGSLASTV SKSRKSVKEE YRRKERECGD
AIAAAEKSKN KYFNFCNELE KLRTGDPSKK TFTLKGSKTG TQQEEELSRK IEIADQDYRA
KVHQCKKLKD ELLMVHRPAQ VKALKGLILE IDTAMSLQLQ KYTTWNETLV MRSGILISPL
HEDSNKPSIK KIAASVDNEK DLYEFLTKQG TTSLNRWLTP VEYKVHPLLG NNLRKDSQRR
NITPTSGAVA GAAVGAGVGA ASSSPLSPLP ASTSYSPTLD PKVVGSRLSG PRELQVSETA
STVSVPPGVK QNLATFGVPI DVLVDNDTGS VPAIVRQCIQ VIEKYGLDLE GIYRVSASVT
KVKELRELID RDPANIALIG PSSPDHVLDD DIYVAATILK LFFKSLPEPL LTNALYQDFL
DAVKDDSGST KISTRLHQIA YELPDGPYWT LRSLLFHLNK IAAHQDVNRM TIRSLSIVWG
EVLLYSEVAN TEDMSYKAKV VEELLKAANL IYEAEP
//
