ID C4TG55_9NOCA Unreviewed; 399 AA.
AC C4TG55;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:BAH10737.1};
OS Nocardia arthritidis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=228602 {ECO:0000313|EMBL:BAH10737.1};
RN [1] {ECO:0000313|EMBL:BAH10737.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFM 10035 {ECO:0000313|EMBL:BAH10737.1};
RX PubMed=19833784; DOI=10.1099/jmm.0.011346-0;
RA Takeda K., Kang Y., Yazawa K., Gonoi T., Mikami Y.;
RT "Phylogenetic studies of Nocardia species based on gyrB gene analyses.";
RL J. Med. Microbiol. 59:165-171(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; AB450769; BAH10737.1; -; Genomic_DNA.
DR AlphaFoldDB; C4TG55; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 323..399
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 89..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAH10737.1"
FT NON_TER 399
FT /evidence="ECO:0000313|EMBL:BAH10737.1"
SQ SEQUENCE 399 AA; 44145 MW; A9CA4C31E7BB47A4 CRC64;
NALSSRLEAE IDHDGYHWSQ TYKDAIPGKL IQGEPTKKTG TTIRFWADPE IFETTTYNFE
TVARRLQEMA FLNKGLTIKL TDERVSDSDV TDEVVSETAE APKHAEEGTA PAEHKVKTRT
YHYPGGLEDF VRHINRTKQP IHNSVVGFTG KGTGHELEVA MQWNSGYSES VHTFANTINT
HEGGTHEEGF RAALTTVVNK YAKDKRLIKE KDGNLTGDDI REGLAAIVSV KVGEPQFEGQ
TKTKLGNTEV KSFVQRTCNE HLTHWFEANP ADAKTIVNKA VSSAQARVAA RKARELVRRK
SATDLGGLPG KLADCRSKDP SKSEIYIVEG DSAGGSAKSG RDSMYQAILP LRGKIINVEK
ARIDKVLKNN EVQSIITAFG TGIHDEFDIG KLRYHKIVL
//