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Database: UniProt
Entry: C4TG55_9NOCA
LinkDB: C4TG55_9NOCA
Original site: C4TG55_9NOCA 
ID   C4TG55_9NOCA            Unreviewed;       399 AA.
AC   C4TG55;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE   Flags: Fragment;
GN   Name=gyrB {ECO:0000313|EMBL:BAH10737.1};
OS   Nocardia arthritidis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=228602 {ECO:0000313|EMBL:BAH10737.1};
RN   [1] {ECO:0000313|EMBL:BAH10737.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IFM 10035 {ECO:0000313|EMBL:BAH10737.1};
RX   PubMed=19833784; DOI=10.1099/jmm.0.011346-0;
RA   Takeda K., Kang Y., Yazawa K., Gonoi T., Mikami Y.;
RT   "Phylogenetic studies of Nocardia species based on gyrB gene analyses.";
RL   J. Med. Microbiol. 59:165-171(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC       {ECO:0000256|ARBA:ARBA00010708}.
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DR   EMBL; AB450769; BAH10737.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4TG55; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.670; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   InterPro; IPR001241; Topo_IIA.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR000565; Topo_IIA_B.
DR   InterPro; IPR013759; Topo_IIA_B_C.
DR   InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR   InterPro; IPR018522; TopoIIA_CS.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR   Pfam; PF00204; DNA_gyraseB; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   PRINTS; PR01159; DNAGYRASEB.
DR   PRINTS; PR00418; TPI2FAMILY.
DR   SMART; SM00433; TOP2c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR   PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          323..399
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   REGION          89..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAH10737.1"
FT   NON_TER         399
FT                   /evidence="ECO:0000313|EMBL:BAH10737.1"
SQ   SEQUENCE   399 AA;  44145 MW;  A9CA4C31E7BB47A4 CRC64;
     NALSSRLEAE IDHDGYHWSQ TYKDAIPGKL IQGEPTKKTG TTIRFWADPE IFETTTYNFE
     TVARRLQEMA FLNKGLTIKL TDERVSDSDV TDEVVSETAE APKHAEEGTA PAEHKVKTRT
     YHYPGGLEDF VRHINRTKQP IHNSVVGFTG KGTGHELEVA MQWNSGYSES VHTFANTINT
     HEGGTHEEGF RAALTTVVNK YAKDKRLIKE KDGNLTGDDI REGLAAIVSV KVGEPQFEGQ
     TKTKLGNTEV KSFVQRTCNE HLTHWFEANP ADAKTIVNKA VSSAQARVAA RKARELVRRK
     SATDLGGLPG KLADCRSKDP SKSEIYIVEG DSAGGSAKSG RDSMYQAILP LRGKIINVEK
     ARIDKVLKNN EVQSIITAFG TGIHDEFDIG KLRYHKIVL
//
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