ID C4TIJ5_ECO57 Unreviewed; 777 AA.
AC C4TIJ5;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Putative P4-specific DNA primase {ECO:0000313|EMBL:BAH79233.1};
OS Escherichia coli O157:H7.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334 {ECO:0000313|EMBL:BAH79233.1};
RN [1] {ECO:0000313|EMBL:BAH79233.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=990281 {ECO:0000313|EMBL:BAH79233.1};
RX PubMed=19564451; DOI=10.1101/gr.089615.108;
RA Ooka T., Ogura Y., Asadulghani M., Ohnishi M., Nakayama K., Terajima J.,
RA Watanabe H., Hayashi T.;
RT "Inference of the impact of insertion sequence (IS) elements on bacterial
RT genome diversification through analysis of small-size structural
RT polymorphisms in Escherichia coli O157 genomes.";
RL Genome Res. 19:1809-1816(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB471558; BAH79233.1; -; Genomic_DNA.
DR AlphaFoldDB; C4TIJ5; -.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003896; F:DNA primase activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01029; TOPRIM_primases; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR InterPro; IPR004968; DNA_primase/NTPase_C.
DR InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR InterPro; IPR045455; NrS-1_pol-like_helicase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014818; Phage/plasmid_primase_P4_C.
DR InterPro; IPR013237; Phage_T7_Gp4_N.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35372; ATP BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR35372:SF2; SF3 HELICASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08706; D5_N; 1.
DR Pfam; PF19263; DUF5906; 1.
DR Pfam; PF03288; Pox_D5; 1.
DR Pfam; PF08273; Prim_Zn_Ribbon; 1.
DR Pfam; PF13362; Toprim_3; 1.
DR SMART; SM00885; D5_N; 1.
DR SMART; SM00778; Prim_Zn_Ribbon; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51206; SF3_HELICASE_1; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 208..296
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 474..627
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51206"
SQ SEQUENCE 777 AA; 84812 MW; 21DEE28B6E0A106F CRC64;
MKMNVTATVS HALGHWPRIL PALGIQVLKN RHQPCPVCGG SDRFRFDDRE GRGTWYCNQC
GAGDGLKLVE KVFGVSPSDA ATKVAAVTGS LPPADPAVTA AAGAETDAAR KNAAALAQTL
MAKTRPGTGN AYLTRKGFPG RECRMLTGTH RAGGVSWRAG DLVVPLYDDS GELVNLQLIS
ADGRKRTLKG GQVRGTCHTL EGQNQAGKRL WIAEGYATAL TVHHLTGETV MVALSSVNLL
SLASLARQKH PACQIVLAAD RDLSGDGQKK AAAAADACEG VVALPPVFGD WNDAFTQYGG
EATRKAIYDA IRPPAESPFD TMSEAEFSAM STSEKAMRIY EHYGEALAVD ANGQLLSRYE
NGVWKVLPPQ DFARDVAGLF QRLRAPFSSG KVASVVDTLK LIIPQQEAPS RCLIGFRNGV
LDTQNGTFHP HSPSHWMRTL CDVDFTPPVE GETLETHAPA FWRWLDRAAG GRAEKRDVIL
AALFMVLANR YDWQLFLEVT GPGGSGKSIM AEIATLLAGE HNATSATIET LESPRERAAL
TGFSLIRLPD QEKWSGDGAG LKAITGGDAV SVDPKYRDAY STHIPAVILA VNNNPMRFTD
RSGGVSRRRV IIHFPEQIAP QERDPQLKDK ITRELAVIVR HLMQKFSDPM LARSLLQSQQ
NSDEALNIKR DADPTFDFIG YLETLPQTSG MYMGNASIIP RNYRKYLYHA YLAYMEANGY
RNVLSLKMFG LGLPVMLKEY GLNYEKRHTK QGIQTNLTLK EESYGDWLPK CDDPATT
//