ID   C4WVD4_ACYPI            Unreviewed;       166 AA.
AC   C4WVD4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00012256};
DE            EC=2.1.2.1 {ECO:0000256|ARBA:ARBA00012256};
DE   AltName: Full=Glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00032953};
DE   AltName: Full=Serine methylase {ECO:0000256|ARBA:ARBA00031137};
OS   Acyrthosiphon pisum (Pea aphid).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC   Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon.
OX   NCBI_TaxID=7029 {ECO:0000313|EMBL:BAH71854.1};
RN   [1] {ECO:0000313|EMBL:BAH71854.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LSR1 {ECO:0000313|EMBL:BAH71854.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:BAH71854.1};
RA   Shigenobu S., Nakabachi A., Richards S.;
RT   "A full-length cDNA resource of the pea aphid, Acyrthosiphon pisum.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777}.
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DR   EMBL; AK341467; BAH71854.1; -; mRNA.
DR   AlphaFoldDB; C4WVD4; -.
DR   UniPathway; UPA00193; -.
DR   GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR001085; Ser_HO-MeTrfase.
DR   InterPro; IPR039429; SHMT-like_dom.
DR   PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11680:SF35; SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          45..160
FT                   /note="Serine hydroxymethyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00464"
SQ   SEQUENCE   166 AA;  18306 MW;  BDC59BF6429E10F6 CRC64;
     MYLRPIIRTL VNAQRLHFNN KFVTMSAMEA KYSTKISDPT LSLPLETADP ELYALVSQES
     QRQKKGLELI ASENFTSVSV LQCLGSCLTN KYSEGLPGAR YYGGNQVIDQ IEVLCQKRCL
     EAFSLDPNLW GVNVQPYSGS PANVEAYTAL IGGGKGRIMG GYFINI
//