ID C4XV92_DROMO Unreviewed; 1107 AA.
AC C4XV92;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=Venus kinase receptor {ECO:0000313|EMBL:DAA06504.1};
DE Flags: Fragment;
GN Name=VKR {ECO:0000313|EMBL:DAA06504.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:DAA06504.1};
RN [1] {ECO:0000313|EMBL:DAA06504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12554084; DOI=10.1016/S0166-6851(02)00249-9;
RA Vicogne J., Pin J.P., Lardans V., Capron M., Noel C., Dissous C.;
RT "An unusual receptor tyrosine kinase of Schistosoma mansoni contains a
RT Venus Flytrap module.";
RL Mol. Biochem. Parasitol. 126:51-62(2003).
RN [2] {ECO:0000313|EMBL:DAA06504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19461966; DOI=10.1371/journal.pone.0005651;
RA Ahier A., Rondard P., Gouignard N., Khayath N., Huang S., Trolet J.,
RA Donoghue D.J., Gauthier M., Pin J.P., Dissous C.;
RT "A new family of receptor tyrosine kinases with a venus flytrap binding
RT domain in insects and other invertebrates activated by aminoacids.";
RL PLoS ONE 4:E5651-E5651(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR EMBL; BK006720; DAA06504.1; -; mRNA.
DR AlphaFoldDB; C4XV92; -.
DR EnsemblMetazoa; FBtr0429817; FBpp0387239; FBgn0281326.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF489; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:DAA06504.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000313|EMBL:DAA06504.1};
KW Transferase {ECO:0000313|EMBL:DAA06504.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 660..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 728..1003
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 760
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:DAA06504.1"
FT NON_TER 1107
FT /evidence="ECO:0000313|EMBL:DAA06504.1"
SQ SEQUENCE 1107 AA; 126922 MW; 03EEE89C2BCD4E65 CRC64;
IFLKEVLNYK DVQIIPLVFE NSSDPENALR TLKYVFYSVE EYTNPNCANI KCATLIAEWR
DDSYFITEEL YDSYLNVVWL GHQFRDTIQE LDTIYKSSYT RGQKRFVVLH WIPSDVINAN
IKFTQISLPR CEDHEYLKRS NCRYELTPIL KYYPGSLIYD KRMMYALRNF YINDTDLENI
LNELSVQRAY TKDSEELFNN VACNWLLQNF KTYSQWVLPK TVKTLSIGGI FPLHITDRGH
ANIIEASQKA VDVINENKTI LPNYHLELLI KDGQCKSDMV LKSFIHYFNE PNLLGVLGPA
CSETVEPIAG ISKHLNMMVI SYSAEGDSFV DREAYPYFFR TIGSNSEYVD AYIKIMQRLG
WTRVSTLTED TQQYTGYLSR MENKLRLYNF TLAFSRKVPS DVTATDMREH LVKLKESYSR
IIIAELQSDN AAITICEAIK LGMTQTENYV WFLPSWLSKD FKMWSIKVDN RCSIDQFRNA
IEGHLSIRHT PFGELNAEMQ EGISINSWLT TYKNMYPSFS SYVGFVYDAV WTYALAAHKL
LENNTYAFNE LRSIEVTKQL SKLISETDFN GLSGNVRFGT GEFGGSRIID LDILQWTNST
HERIGLFKPI IEGEAANMHI NGGRLIFSTE KAFHGQVPED GRYDCSFSAL ARCLDVTCDI
ASMIFIIFQC LTVIVLMSLI SCYFWKKRFD RKVRRSAQIM KMFGIDLISP SRNKVNTLDK
WEVQKDNVVI NRRLGEGAFG TVYGGEARLD SDEWTAVAVK TLKAGQSTED RLDFLAEAEA
MKKFNHKNII KLLGVCLQTE PIYTIMEFML YGDLKTYLLA RRNMVNEKLT DESDISSKRL
TMYAMDVASG LAYLAEQKYV HRDIACRNCL VNSQRVVKIG DFGMARPTFE SDYYCFNRKG
VRKLFPVRWM PPETLSLGLF TPGSDIWSFG VVLFEIITFG SYPYQGLTNN QVLDFVKAGN
TLQIPSGVKP QLEGLLKSCW SQDVSKRPTA LEIIEYISNY PRLLTPSIDF SGTAVQLSES
ECDEVELLPT CHKPFSSSNE PTLDLLPHHQ RCFDNFHKNN TENEFPKLGE NDGSDSPCND
ISFSQTTPDG YSIMAPLLKH QLDDISN
//