ID C4XV95_DROPE Unreviewed; 1072 AA.
AC C4XV95;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Venus kinase receptor {ECO:0000313|EMBL:DAA06507.1};
DE Flags: Fragment;
GN Name=VKR {ECO:0000313|EMBL:DAA06507.1};
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234 {ECO:0000313|EMBL:DAA06507.1};
RN [1] {ECO:0000313|EMBL:DAA06507.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12554084; DOI=10.1016/S0166-6851(02)00249-9;
RA Vicogne J., Pin J.P., Lardans V., Capron M., Noel C., Dissous C.;
RT "An unusual receptor tyrosine kinase of Schistosoma mansoni contains a
RT Venus Flytrap module.";
RL Mol. Biochem. Parasitol. 126:51-62(2003).
RN [2] {ECO:0000313|EMBL:DAA06507.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19461966; DOI=10.1371/journal.pone.0005651;
RA Ahier A., Rondard P., Gouignard N., Khayath N., Huang S., Trolet J.,
RA Donoghue D.J., Gauthier M., Pin J.P., Dissous C.;
RT "A new family of receptor tyrosine kinases with a venus flytrap binding
RT domain in insects and other invertebrates activated by aminoacids.";
RL PLoS ONE 4:E5651-E5651(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BK006723; DAA06507.1; -; mRNA.
DR AlphaFoldDB; C4XV95; -.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IEA:EnsemblMetazoa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:EnsemblMetazoa.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:EnsemblMetazoa.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IEA:EnsemblMetazoa.
DR GO; GO:0031631; P:negative regulation of synaptic vesicle fusion to presynaptic active zone membrane; IEA:EnsemblMetazoa.
DR GO; GO:0042048; P:olfactory behavior; IEA:EnsemblMetazoa.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF489; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:DAA06507.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000313|EMBL:DAA06507.1};
KW Transferase {ECO:0000313|EMBL:DAA06507.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 662..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 730..1005
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 762
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:DAA06507.1"
FT NON_TER 1072
FT /evidence="ECO:0000313|EMBL:DAA06507.1"
SQ SEQUENCE 1072 AA; 122785 MW; 65FA2857BAF9A706 CRC64;
MFLKDVLGYR NVRIVPINTY DAWTTLDLVI NFLSAQVYRN PNCDGYKCVT ILAEFRNDSS
FVEDQLDETE MMVNVLWIGE KFRETIDWLI RKYEQKFSDG SKRLIILHWT PSEIIFAQNT
FQQITMPRCE DYTYLQRSGC KYELTPILKY YAKSLASDKQ LMYALRYFNL SDKHLSNIRM
DLKYYRKDLS ISATEIYDKA ACHWLLENRN YYNLWKESNQ PITLLIGGIF PINITYRGHE
NVMNVAKHAA SVINKDQTIL PGYHLEILVN NGQCKSDMVM KSFIHYYSIP NILGVLGPAC
SETVEPIAGI SKHMNMMIMS YSAEGATFSN REAYPNFFRT IGSNRLFVDA YLDIMEKFKW
SRVASLTENE SNDNTSHMEK KLKLRNFTLI INRKLQPVVT PMEMKEHLHK LQEAHAKIII
ADIVHVQNAA IVFCEAHKLG MTQQDDYIWF LPPWLPKDFQ MWQRMVNSSC TASELRNLQA
IEGHFSVRHS PFGNPEALMQ EGKPIRAWLD EYRNQSGEPS NYAGFTYDAV WAYAIAAHKL
LLKDQYAVNY LRNTEVVNRF RELIGQTNFE GLSGNVSFAQ GELGGSRIID LDILQWKNSS
LAKVGKFKPS VNGKGASMHV CGGNLSLNLN NILWLKGVVP EDGRYDCRFS RLARTLRVDC
DIAAMVFAIV LCLLAISLIS FTSFWFWKKR YSRKLKRSAQ IMKMFGIDLL SPSQNKTNTL
DKWEIPKENV VVNRRLGEGA FGMVYGGEAQ ITSGQWTAVA VKTLKSGQSM EDRLDFLSEA
EAMKKFDHKN IIKLLGVCLQ NEPIYTIMEF MLYGDLKTYL LARRNMVKEK FTDESDISPK
RLTLYAMDVA CGLAYLAEKK YVHRDIALRN CLVNAQRVVK IADFGMARPT FESDYYRYNR
KGARKLFPVR WMPPETLALG LFTPASDIWS FGVVLYEVIS FGSYPYQGLT NNQVLEYVKN
GKTMHIPLGV KPQLEGLLKA CWSQEASKRP TALEVVEYIS NYPRLLTPAL EVPATSIELP
ESQSDQIQEC EELSNLNTSA NTKPDTIFKP LCDTGSFTPI TPDGYSIMSP LL
//
