ID C4XX47_CLAL4 Unreviewed; 738 AA.
AC C4XX47;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN ORFNames=CLUG_00520 {ECO:0000313|EMBL:EEQ36397.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ36397.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ36397.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ36397.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; CH408076; EEQ36397.1; -; Genomic_DNA.
DR RefSeq; XP_002619361.1; XM_002619315.1.
DR AlphaFoldDB; C4XX47; -.
DR STRING; 306902.C4XX47; -.
DR GeneID; 8500050; -.
DR KEGG; clu:CLUG_00520; -.
DR VEuPathDB; FungiDB:CLUG_00520; -.
DR HOGENOM; CLU_010129_3_2_1; -.
DR InParanoid; C4XX47; -.
DR OMA; LEYKFLH; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000007703};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 442..523
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 125..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 83891 MW; 7F5B685F32445A1A CRC64;
MSDKHALFDT VFPKTVKAVR AASALAAQDI NFYTSLDKGI SSDVKDASSS LLALANKLLS
KTTKDFEFIE YGEENIVSKL NWKRVSDVLD TCFEKADLAL DEVKNPQRAS TSHMIYLKDS
SDEKKATEVK VKPQENFRST VDNSDSSPFK PRLENKPYAL KSLEESLKLR FPDPTDDGKV
SAPHYAHPYE FEIMNQPYPE SCLQVNKPVP STDWATTAAK WVDTVDALQE MIEALRSSTE
IAIDLEHHDY RSYYGITCLM QISNREQDWI VDTLALHDDL RDLNEIFANP AILKVLHGAN
MDIIWLQRDL GLYIVSLFDT YHASKKLGFP KFSLAYLLEN FAHFKTSKKY QLADWRIRPL
TDAMMQYARA DTHFLLNIYD QLRNKLLNAG QGKVQEVLYE SRKVASRRFE FNSFKQDQTD
NWMHSYGGMG QERWVMNQYN IEPERIEIVQ ALINWRDKVA REKDESTRYI MSNQVLANLS
SLVAPVDASK VHNAAGSQYS IVRQNSKELA ELIEKYLATV GHSANNENVT SFDLTEVNYD
KASEISKHFT DLTKSVPTAT NLSLSDKDSR LLSKFAGKSF SLSAESFEPS TNERIRISQE
ELMKRATLLS ESLAENLTSF EIENEKSKID NMEEAEEKID KSATESPQRQ SSEEDKDAIV
VLSGKKSKKS FNKKQSTADE ELFDYSTVEE KVLANVKNGN TKKRSFDPFS RQGTGPKAAK
RSRNVPTGKS TSFVKKRN
//
