ID C4Y2K3_CLAL4 Unreviewed; 805 AA.
AC C4Y2K3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Heat shock protein 78, mitochondrial {ECO:0008006|Google:ProtNLM};
GN ORFNames=CLUG_02766 {ECO:0000313|EMBL:EEQ38640.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ38640.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ38640.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ38640.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR EMBL; CH408078; EEQ38640.1; -; Genomic_DNA.
DR RefSeq; XP_002617322.1; XM_002617276.1.
DR AlphaFoldDB; C4Y2K3; -.
DR STRING; 306902.C4Y2K3; -.
DR GeneID; 8497631; -.
DR KEGG; clu:CLUG_02766; -.
DR VEuPathDB; FungiDB:CLUG_02766; -.
DR HOGENOM; CLU_005070_4_0_1; -.
DR InParanoid; C4Y2K3; -.
DR OMA; SKMMQGE; -.
DR OrthoDB; 35211at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432};
KW Reference proteome {ECO:0000313|Proteomes:UP000007703}.
FT DOMAIN 127..272
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 528..669
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 701..790
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT COILED 341..421
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 805 AA; 89996 MW; BEAA90298FF12CDB CRC64;
MLRANLRPKN LARLAESRTP LASSSAARAL TIGARPTLFS TNATSYAPVP SLVSATFRQS
APFVPKRLFH SSGPRQLQMQ QNNDDNVPAL EKYGSDLTQM ARDGKLDPVI GRDEEIRRTI
QILSRRTKNN PVLIGNAGTG KTAVMEGLAQ RIIKGEVPES MKNKSIITLD LAGIISGAKF
RGDFEEKLKK ILKEVEDKKG SVILFVDELH LLMGLGKAEG SIDASNLLKP ALARGKLSLC
GATTIEEYRK YVEKDAALAR RFSSVLVSEP SVQDTISILR GLKERYEVHH GVRIADGALV
TAALYSNRYI TDRFLPDKAI DLVDEACSTL RLQHESKPDA IAQLDRQIMT IEIELESLRK
EEDSLSVDRR KKLEEDLAVK KAELKEFTEQ WESEKQAIDS VKSAKANLEQ ARFDLEQAQR
EGNYAKASEL QYATIPKLER ELQQLTDSED VIKSTSLLHD SVTSDDIAAV ISKMTGIPLS
SLMKGEKDKL LDMEVILKQH VVGQDEAIHA VSDAVRLQRA GLTSDKRPIA SFMFLGPTGT
GKTELTKQLA EFLFNDTSSV IRFDMSEFQE KHTVSRLIGS PPGYVGYEDS GELTEAVRRK
PYAVVLFDEF EKAHKDVSKL LLQVLDEGSL TDSHGKKIDF RNTIIVMTSN IGQEILLADK
EASEDGKIRE SVKNNVVESL RHHYPPEFLN RLDDILVFNR LSKSSLRNIL EIRLREVQDR
LDDKRMSLSL SDEAKDFLAD KGYDPIYGAR PLNRALQKEL LNPMAMLMIK GQIREGEKVN
VSVKDKKLYI EPNHTEDETL SKEST
//
