ID C4Y3R3_CLAL4 Unreviewed; 450 AA.
AC C4Y3R3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Metacaspase-1 {ECO:0000256|ARBA:ARBA00016994};
GN ORFNames=CLUG_03176 {ECO:0000313|EMBL:EEQ39050.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ39050.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ39050.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ39050.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the peptidase C14B family.
CC {ECO:0000256|ARBA:ARBA00009005}.
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DR EMBL; CH408078; EEQ39050.1; -; Genomic_DNA.
DR RefSeq; XP_002617732.1; XM_002617686.1.
DR AlphaFoldDB; C4Y3R3; -.
DR STRING; 306902.C4Y3R3; -.
DR GeneID; 8498298; -.
DR KEGG; clu:CLUG_03176; -.
DR VEuPathDB; FungiDB:CLUG_03176; -.
DR HOGENOM; CLU_029389_0_1_1; -.
DR InParanoid; C4Y3R3; -.
DR OMA; DEMHNIM; -.
DR OrthoDB; 1077459at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.12660; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR PANTHER; PTHR48104; METACASPASE-4; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022807};
KW Reference proteome {ECO:0000313|Proteomes:UP000007703};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 154..441
FT /note="Peptidase C14 caspase"
FT /evidence="ECO:0000259|Pfam:PF00656"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 50175 MW; 79BEB0A8CE62F97E CRC64;
MFPGNGHQSY NQGSYPNQYG NQYGNQYGNQ YENNQYGNNQ YGNQQYGNQY GNQPYGNTQY
ENRGQYENQD FRPPPGPPSL NSPQFQQQQF RYQQQQQQQQ QQHYERPSAP PPNSSYDSSG
HYNEQAPSGP PPTAPQSFGG NSNMSFQYSN CSGRKKALLI GINYFGSKNE LRGCINDVKN
MSRFLHDFYG YSYDDMVILT DDQREMARVP TRDNIIRAMQ WLVSGAQPND SYFFHISSHG
GLVPDQNGDE ESGFDSCVYP VDFERSGPII DDEMHDIMVK PLPPGCRLMA LFDCCHSGTA
LDLPFVYSTK GVVKEPNLWK DAGAGALKAF MNYETGNISG ALSSLTGVVK KVSKFGNGAS
RDDVIRSKMS PADVISLSGC KDDQTSADAQ EAGANTGAMS WAFISVLSQN RNQSYLSLLN
GMRNLLAAKY SQKPQLSASH PQDMNLQFFM
//
