ID   C4Y595_CLAL4            Unreviewed;       773 AA.
AC   C4Y595;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=CLUG_03329 {ECO:0000313|EMBL:EEQ39201.1};
OS   Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Clavispora.
OX   NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ39201.1, ECO:0000313|Proteomes:UP000007703};
RN   [1] {ECO:0000313|EMBL:EEQ39201.1, ECO:0000313|Proteomes:UP000007703}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ39201.1,
RC   ECO:0000313|Proteomes:UP000007703};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
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DR   EMBL; CH408079; EEQ39201.1; -; Genomic_DNA.
DR   RefSeq; XP_002616088.1; XM_002616042.1.
DR   AlphaFoldDB; C4Y595; -.
DR   STRING; 306902.C4Y595; -.
DR   GeneID; 8497411; -.
DR   KEGG; clu:CLUG_03329; -.
DR   VEuPathDB; FungiDB:CLUG_03329; -.
DR   HOGENOM; CLU_361687_0_0_1; -.
DR   InParanoid; C4Y595; -.
DR   OrthoDB; 5560940at2759; -.
DR   Proteomes; UP000007703; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007703}.
FT   DOMAIN          414..595
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          38..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          171..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          364..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..96
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..148
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   773 AA;  82691 MW;  7996D86E4D2BE354 CRC64;
     MYVLVRMYSV CTCSYSNCMS IKLRTGCFCA MFFAPSQKPP NSGQARVPPD GNELAKVNKQ
     KEIQTNNQDA GFGREKARTR EEFESKKLES EKLESEPIYA SFEMQGGRTK GKGGRGEESH
     GSKCKDTSDE SRNTIKQHND SSYTEKHHYA ESEISDLDLS GLGGGRVVSA DKREAEESQA
     IGGEETQSRR SYFDRQSTTN KEWNAEENPQ ATLGILEIST SSIPKANTVS ILGKIDFGDT
     LPESKVSKNT PVPGAHGCHG ENTLKAEAKA ETSHGAIPLP ASTIPLPAST IPLPASATTS
     KPDTISSLSN SANFPASANL SALANSARSN PTANPRSTEL ANSANFPASA NLSALANLSA
     GTSGNSNSAQ CSGSPDLAQA DSQAKSSMPL DSPDAGDASN ASNAIVGVEG AQAGALRLVR
     ELAASELTFV AGLRLWANLV LDPLAARCRH LGISCAPLLQ HRATVLHMAR IHQAFCCELE
     HSTPARAAAA LEKLLGDPVY CAYPGTAHAV ASLIARRIAP FDTDYASCIG RFLERHQPPH
     RHLDLSPGSF LSQPISRVAR YRLFLLGLAA LEPQSQCFSR ALEASTGLLA RANAAAERDA
     ARARFLVLMD ERIDFGRTGF CAAFFGAVRC AAAPEVAWVE AGAFGPRAVF PRRMRLYIHA
     RHFLVTQIKG GAERIRLIVP IRNCQLCPSA SKQEGLWTAS SRALKILFAR GAARHEVLFA
     GASHHESAEI RRCCGHFSQE PLSPEAEPAN DIVIGPRLAQ AYGAICVVLE AES
//