ID C4YGB6_CANAW Unreviewed; 952 AA.
AC C4YGB6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=CAWG_00237 {ECO:0000313|EMBL:EEQ42040.1};
OS Candida albicans (strain WO-1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294748 {ECO:0000313|EMBL:EEQ42040.1, ECO:0000313|Proteomes:UP000001429};
RN [1] {ECO:0000313|EMBL:EEQ42040.1, ECO:0000313|Proteomes:UP000001429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-1 {ECO:0000313|EMBL:EEQ42040.1,
RC ECO:0000313|Proteomes:UP000001429};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR EMBL; CH672346; EEQ42040.1; -; Genomic_DNA.
DR AlphaFoldDB; C4YGB6; -.
DR PaxDb; 5476-C4YGB6; -.
DR VEuPathDB; FungiDB:CAWG_00237; -.
DR HOGENOM; CLU_002323_0_0_1; -.
DR OMA; IMFGRQE; -.
DR Proteomes; UP000001429; Chromosome 1, Supercontig 1.1.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 3.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 1.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5..307
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 755..924
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 809..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 952 AA; 104823 MW; A82C89C6D6312BD6 CRC64;
MALVSAAPYL ALLGEPDSTL KSYALSSLNQ VVDQLWAEIA NNITELEELY EDDSFDRKEL
AALVISKVYY NLGDFDAAVK YALYAGNEFN LEEKSQYMET IVSQCINLYN SLSQQKFNDS
TTKIDPRLTA IFEKMLNKCL KANEVKLSLG VALESYRLDL VESILQDQIK NNEEQALNLI
NYVLVCSNNT VSNTNFRVQV LNSLISLLLS LKKHQDFFTI IKIIVQLNDS ELAVKLFQEL
INQNEDLIAY QAAFDLVNAA SQELLDLVME KLSNAKESEN GTLKKILNIL SGVPTCDLDN
TFLFKNNNAD ITILNKTKNL LDGRSSIFHS AVTFANAFMH AGTTDDSFFR KNLEWLGRAT
NWSKFSATAA LGVIHKGNLS QGRTILKPYL PGSSGSANNK GGSLFALGLI FAGHGREVIG
TLKSFIDDNG NAAGSNDIDI QLHGAALGAG VAGMGSKSES LYESLKVVLY SDSAISSQAA
ALGMGLVMLG SGNEEAIKDM LTYALETQHE NIIRGLAIGI ALLSYGREEK ADEIIDQLMN
QESSILRYGG AFTIALAYAG TGNNNAIKKL LHFAVSDPSD DVRRASVLSL GFLLIRDYTA
APQIVKLLSQ SHNPHVRYGT ALALGISCAG RAYPAAIEVL EPLTKDAVDF VRQGALMASS
MILIQQNEFI YPKVKEFTKQ YADTIKNKHE DALAKFGATL AQGIIDAGGR NSTINLENSQ
TNTLNTKAIV GLTLFVQSWY WFPLAHFLSL SFAPTSIIGV RGQDLKAPKF ELNCHANPEY
FQYPPKVEEA KEKQPDKLAT AVLSTTAKAK TRAKKKQSQK EGGDIKTEDK MDVDEETKPK
VDAKESNDDE KKETKKQPVS DEPVTVRYAR TPYKISNLSR VLPVQSNFIS FIKDDRFVPV
RKYRGSSGIV VLQDNKPEEK VEFIKTVRQL NITEAPVPEP FTLSGEDLQD DE
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