ID C4YL82_CANAW Unreviewed; 1070 AA.
AC C4YL82;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=CAWG_01599 {ECO:0000313|EMBL:EEQ43363.1};
OS Candida albicans (strain WO-1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294748 {ECO:0000313|EMBL:EEQ43363.1, ECO:0000313|Proteomes:UP000001429};
RN [1] {ECO:0000313|EMBL:EEQ43363.1, ECO:0000313|Proteomes:UP000001429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-1 {ECO:0000313|EMBL:EEQ43363.1,
RC ECO:0000313|Proteomes:UP000001429};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
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DR EMBL; CM000309; EEQ43363.1; -; Genomic_DNA.
DR AlphaFoldDB; C4YL82; -.
DR PaxDb; 5476-C4YL82; -.
DR VEuPathDB; FungiDB:CAWG_01599; -.
DR HOGENOM; CLU_001832_6_3_1; -.
DR OMA; LYDLWAI; -.
DR Proteomes; UP000001429; Chromosome R.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0022613; P:ribonucleoprotein complex biogenesis; IEA:UniProt.
DR GO; GO:0006396; P:RNA processing; IEA:UniProt.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 368..539
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 561..745
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 110..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 327..354
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 114..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 122003 MW; 5D233E971951DF96 CRC64;
MRIFFFVGDV SIFTTITISF LEFNIDNNTF PSPRINNIST MNILDDLDDE LDELETTTKP
KVKILNKKKE HKPIVDDDLD LDLDDDDFNL PKIKPPTKFK KMKREDALRI KKETPSSLSP
SSSVPSKPQG VSSNLPFRPA TPPVSEPSTY EEEDLGDINL DNFSNIEADR EWYNIDEESA
LARDNEIDED LPQRQRKRIR NTRHPKRTPK TSFNESGATF NEFGEYIDYD HQQSLNELNR
IPITSHVFIP PFLENSKQYL QLQISGSSIR GIGPTVNPVK DPTSELASMA KQGSFVVQNR
RSKRERALQA KEAAGVENSN IGSIIDAANT TEEIKQEEKN ADVNETKHQD IQQQRKSLPA
FAVRNDLLTT IRDNQVTIVI GETGSGKTTQ LTQFLYEDGF GANIDKNGEK RIIACTQPRR
VAAMSVAKRV SEEMNCKLGE EVGYSIRFED KTDNKKTVIK YMTEGILLRE ILADPMLANY
SCIIMDEAHE RSLNTDILLG LFKNLLAKRK DLKLIVTSAT MNANRFTKFF GAAPQFHIPG
RTFPVEVFFN RDVNMDYVEM AVKQVLTIHL GRWNADNNNA NDGDILVFMT GQEDIEITCD
LIKEKLNLLE DPPPLNIFPI YSTMPQDLQK KIFNKTNLQR RKVVVATNIA ETSLTVDGIK
YVIDCGLVKV KVYNPKLGMD TLQVVPISLA NADQRSGRAG RTGAGIAYRL YTEKATEPDS
MYVQPIPEIQ RSNLSNIMLL LKSLKVNDIN SFPFLDPPPK DLLNCSLYDL WAIGALDNLG
ELTKLGHSMT QFPIEPTLAK LILLSTQPEF HCSEEVVTIV AMLSVPNIFN RPKERANEAD
MAREKFIISE SDHLTLLNVF NQWNINLNKF KGNYTKINNW CDKNFLQLKS LYRAKDIKHQ
LMLIMKKNKL AILKSKTDDD IRKCLCASFY QQSAKLTKMN LNGQPEFVNL RHSYMKMFLH
PTSSLLDSNL STNYVIYHEL VLTKKEYMNC VTTVDPIWLL EYGYKFFGVA DSHRNKIDSE
AILNKQKFEK QLLKDKEIYE DIIKQQSKRR SNEISTSNRV SSLFKKQRGI
//
