ID   C4YSM9_CANAW            Unreviewed;       810 AA.
AC   C4YSM9;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Pep3/Vps18/deep orange beta-propeller domain-containing protein {ECO:0000259|Pfam:PF05131};
GN   ORFNames=CAWG_05097 {ECO:0000313|EMBL:EEQ46732.1};
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748 {ECO:0000313|EMBL:EEQ46732.1, ECO:0000313|Proteomes:UP000001429};
RN   [1] {ECO:0000313|EMBL:EEQ46732.1, ECO:0000313|Proteomes:UP000001429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1 {ECO:0000313|EMBL:EEQ46732.1,
RC   ECO:0000313|Proteomes:UP000001429};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC       Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the VPS18 family.
CC       {ECO:0000256|ARBA:ARBA00010454}.
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DR   EMBL; CM000312; EEQ46732.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YSM9; -.
DR   PaxDb; 5476-C4YSM9; -.
DR   VEuPathDB; FungiDB:CAWG_05097; -.
DR   HOGENOM; CLU_003488_0_0_1; -.
DR   OMA; WIQREKW; -.
DR   Proteomes; UP000001429; Chromosome 6.
DR   GO; GO:0098588; C:bounding membrane of organelle; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR007810; Pep3_Vps18.
DR   PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR   Pfam; PF00637; Clathrin; 1.
DR   Pfam; PF05131; Pep3_Vps18; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR   PROSITE; PS50236; CHCR; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          39..362
FT                   /note="Pep3/Vps18/deep orange beta-propeller"
FT                   /evidence="ECO:0000259|Pfam:PF05131"
SQ   SEQUENCE   810 AA;  94406 MW;  622960246DDF7733 CRC64;
     MSSNGHKTKS IKSETNSSYT VHSLDQQQAS ICDNLQQAKF ELEPVHLQFS LSNKLNKLLV
     SSNIMYILLT NVVYKIDLDN PSQVENYALP GKVTNAWLNP NGQTLIVQIE KQAYYTLEKK
     VFKLLKFKNI EVTSIAFSNH NMVVGTKDGI IYVYEKSLKQ VYKVDSPVQG VMFSNDYSQI
     NVLANSLYTW DCFDISYVEL QKVFKQTTPV IKSINPPGIF TSNPQNYVYI SSDNEIITND
     EEIQLDRVDG EFSQIALTSH HLIGIEGNSL KIYNKLNKQL QELSLSENKI RGIAVDNLFN
     TYWVYTKNSV YEFVIENESI SVWYDYYKMG KYSEALKYLD EDDEANFSKR DLVLIKQGYD
     YLQRGGFGIS SDDLSLQIQG IQILAKSTEP FEKVCLMLLN HKESDVLLIE YLLAKLNKKN
     KVRMVVLSAW IIELMVRNYD SRVYEFIKTN YKLLDRPTMY QILNSEKLIF YAELIEDYNF
     ILKYYIDKKN WALAVKTLIK LYTKGDIELV YENATILLMN YPKVTETWLK LDLEYEKLLP
     ALLKHQEQAI HFLQQVIMDK HYKKNKQLNN AYLCLLITKP GTDKQIIKFI NFTSNFDTNF
     ILRLCISHEK FHPAVLIYIE IGLFDQALEL ALKHDLTSLA EFILNKYDED KQVEGIKLED
     ANYNVKRKLW LKFAKYLIDK SDDLNETLHH VINVSMLDLK DLLPLFPETV SINNFKDEIV
     ESLNEYNKRI VHLSLDMNNS SEHLREMKKK VIYNKKKTNV AIIEPGEPCR KCGKLLVQEN
     FVYFLNCHHA FHKECMKKNQ CLLCNDFLNL
//