ID   C4Z8K0_AGARV            Unreviewed;       710 AA.
AC   C4Z8K0;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Sulfatase {ECO:0000313|EMBL:ACR76827.1};
GN   OrderedLocusNames=EUBREC_3099 {ECO:0000313|EMBL:ACR76827.1};
OS   Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835
OS   / VPI 0990) (Eubacterium rectale).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Agathobacter.
OX   NCBI_TaxID=515619 {ECO:0000313|EMBL:ACR76827.1, ECO:0000313|Proteomes:UP000001477};
RN   [1] {ECO:0000313|EMBL:ACR76827.1, ECO:0000313|Proteomes:UP000001477}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / LMG 30912 / VPI
RC   0990 {ECO:0000313|Proteomes:UP000001477};
RX   PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA   Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA   Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA   Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA   Hettich R.L., Gordon J.I.;
RT   "Characterizing a model human gut microbiota composed of members of its two
RT   dominant bacterial phyla.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004936}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP001107; ACR76827.1; -; Genomic_DNA.
DR   RefSeq; WP_012743854.1; NC_012781.1.
DR   AlphaFoldDB; C4Z8K0; -.
DR   STRING; 515619.EUBREC_3099; -.
DR   PaxDb; 515619-EUBREC_3099; -.
DR   KEGG; ere:EUBREC_3099; -.
DR   HOGENOM; CLU_014385_3_2_9; -.
DR   Proteomes; UP000001477; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd16015; LTA_synthase; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR   PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        104..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          269..531
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   REGION          691..710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  79942 MW;  C5B5B087CC742B00 CRC64;
     MKKIFDVLNV IKQKLFVKKD KIHSEKYYRR IDFLNKYSLL FHAIIAMAIV FIVEIISRRS
     FISACKFVDA HTLAFMYNSF LVFVSFSLVY LFRRRAFARV IITGFWTILG IINGCVLSNR
     VTPFGYTDLK CIPELLAMNN TSYFTAQQAT IVVVGLGAFA LFLVALFIKG PKYTGKIRYA
     GISVAFLALL FVAIPVTTNV AQNTNVVASY YSNIAQGYDD YGFVYSFSST VVDRGMKKPE
     DYNKQNVEDV EQKVNSQKQT TTVDGKTGPN IICVLLESFC DPDEINFLQV NEDPIPTFHE
     LEKNYSSGYL NVPVVGAGTA NTEFEMLTGL SMQYFGTGEY PYKTILKQTD CESIASDLSK
     IGYATHVVHN NGGNFYSRTN AFSKMGFDTF TSKELMNITE YTPNGSWPTD DILVSETMKT
     FDATPNQSDF TYIITVGTHG DYPKEPVIEN PTYTVSGVED EGMKNAWTYY VNQLNEADRF
     IKELTDELSK RDEDTIVVMF GDHLPTMGLQ DSDMKSGDIY KTKYITWNNM GLPKEDADLY
     AYQLLAQTTD TVGIHEGTIM NYHQTQMNST DEASYQDGLD LLQYDILYGK RYCYNGTDLY
     PASDLVMGID KVDITNVSDS STSDTVYIYG HNFTNWSKVY INDSKVASTY LSAGVLAINK
     EDISDGDEIT VCQVGSSDTI FRKSENTYTY VDPAVEHDSE SETDEPTENQ
//