ID   C4ZCP4_AGARV            Unreviewed;      1390 AA.
AC   C4ZCP4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=FtsK/SpoIIIE family protein {ECO:0000313|EMBL:ACR74399.1};
GN   OrderedLocusNames=EUBREC_0609 {ECO:0000313|EMBL:ACR74399.1};
OS   Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835
OS   / VPI 0990) (Eubacterium rectale).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Agathobacter.
OX   NCBI_TaxID=515619 {ECO:0000313|EMBL:ACR74399.1, ECO:0000313|Proteomes:UP000001477};
RN   [1] {ECO:0000313|EMBL:ACR74399.1, ECO:0000313|Proteomes:UP000001477}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / LMG 30912 / VPI
RC   0990 {ECO:0000313|Proteomes:UP000001477};
RX   PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA   Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA   Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA   Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA   Hettich R.L., Gordon J.I.;
RT   "Characterizing a model human gut microbiota composed of members of its two
RT   dominant bacterial phyla.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR   EMBL; CP001107; ACR74399.1; -; Genomic_DNA.
DR   STRING; 515619.EUBREC_0609; -.
DR   PaxDb; 515619-EUBREC_0609; -.
DR   KEGG; ere:EUBREC_0609; -.
DR   HOGENOM; CLU_003134_2_1_9; -.
DR   Proteomes; UP000001477; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   CDD; cd00060; FHA; 1.
DR   CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR023839; Firmicutes_EssC_C.
DR   InterPro; IPR002543; FtsK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   NCBIfam; TIGR03928; T7_EssCb_Firm; 1.
DR   PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR   PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR   Pfam; PF01580; FtsK_SpoIIIE; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS50901; FTSK; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00289}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00289}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        154..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          565..759
FT                   /note="FtsK"
FT                   /evidence="ECO:0000259|PROSITE:PS50901"
FT   DOMAIN          898..1081
FT                   /note="FtsK"
FT                   /evidence="ECO:0000259|PROSITE:PS50901"
FT   BINDING         585..592
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
FT   BINDING         914..921
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ   SEQUENCE   1390 AA;  157509 MW;  B2C3807A6537818F CRC64;
     MKMENYGWSI ELNPGYVLII GNAPDAHIQL DSAYGRAVRV GLQVKDDISC AMLSEYSSSY
     NTLVNGKSIQ RIATVKNHDF ISIGDFTAYY NNGKIFFDYG AIRTNGVEVR PESLDIHTTY
     PVFIRNTRIQ AKRDKTPIEI LDPGTIPTKP ELNLVTSLMP SIIMFALVVL LRGVMSKSNG
     AFVAFSICSM GVGVFTSIFG IINKQKKYKK DLVKRRDTYL EYIAKKRNEI EAARREELDC
     LNAQYYSIEQ DIEHIENFDP VLFDRISTDE DFLEVYLGRG NVESLRQVDY KKQEKLEVGD
     DLSSLPEHVA GEYMDIEKAP VVMSLKDANA VGVVGDADSL YSMMKNMIMD IISRQYYGDI
     CIYALLDDNI GKYNWLRGIK ALNSSNGNRN IVCDQESKNR VFENLYKELS IRKDEKVHGR
     FNIIIVMQDY GIKSHPISKF IEHASELDTV FIFFESKLSL LPLYCSRIID IFDNESAMIY
     DSVNKTQKKY FEYENIPDWR VQKAVSILEP VECEEISLAG SLRKNISLFE LLGINSVQAL
     NLKERWNSSK IYETMAVPLG VNVKDEIVYL NLHEKFHGPH GLVAGTTGSG KSEILQTFIL
     GAATLFHPYE IGFVIIDFKG GGMVNQFRKL PHLIGAITNI DGKAIDRSLR SIKAELLKRQ
     NLFAQLNVNH IDKYIKAYKE GQAKVALPHL VIIVDEFAEL KAEQPEFMKE LISAARIGRS
     LGVHLILATQ KPAGQVNDQI WSNSKFKLCL KVQTQEDSNE VLKSPLAAEI KEPGRAYLQV
     GNNEIFELFQ SGYSGSPESI NGEDDTPFDI YELDFSGKKN LVYKHKLENS EQSRSQLEAV
     VEYVDKYCKA DGVKKLPDIC LPALEEVIVY DAELAHNDTP LSMTAVIGIY DDPDRQRQGR
     TVIEIGNKNT IIIGASQFGK TNLLELIVRN LAENYSPEEL SIYIIDFASM VLKNFEKLAH
     VGGVVCPSDD ERLKNLFKYL SEQIEERRER LLEAGVSSYT SYREAGFTDI PQIVVLIDNY
     TALKELYLQD SDILLNLCRE GGSVGISFII SNLQTTGLGY KYLANFSGRI AMFCNESSEY
     MTLYGSCKLR PDETAGRCLT EIDGEIYECQ TFLAFEGTKE IERVNNMHAF VDQINAVYGD
     ITADKIPEIP ELLTPDYVDH TFRRKNDENI IGIAYDTVAP VYTDHNKCNI ITISGADNMG
     RTNFIKYFAL QMLNSEIDTH IYIADDFRRK LSDIGQENVS YDLDPDEFIQ KIIMIEVLLE
     EKYKRLIHQE NPEKENTLII INSQEVYTAI SDSKDALNAL KNIMGKYKVL NVYLLFGAVP
     NAQIAYGSPD IYKMMKETKS ILFFDNLDNC KIVDIPLAIK RKNQKKIEPG DAYYIFEDEV
     SKVRIPLVSD
//