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Database: UniProt
Entry: C5A133
LinkDB: C5A133
Original site: C5A133 
ID   UBIA_ECOBW              Reviewed;         290 AA.
AC   C5A133;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   19-FEB-2014, entry version 33.
DE   RecName: Full=4-hydroxybenzoate octaprenyltransferase;
DE            EC=2.5.1.-;
DE   AltName: Full=4-HB polyprenyltransferase;
GN   Name=ubiA; OrderedLocusNames=BWG_3753;
OS   Escherichia coli (strain K12 / MC4100 / BW2952).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=595496;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MC4100 / BW2952;
RX   PubMed=19376874; DOI=10.1128/JB.00118-09;
RA   Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L.,
RA   Reeves P.R., Wang L.;
RT   "Genomic sequencing reveals regulatory mutations and recombinational
RT   events in the widely used MC4100 lineage of Escherichia coli K-12.";
RL   J. Bacteriol. 191:4025-4029(2009).
CC   -!- FUNCTION: Synthesis of 3-octaprenyl-4-hydroxybenzoate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxybenzoate + farnesylfarnesylgeraniol =
CC       3-octaprenyl-4-hydroxybenzoate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
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DR   EMBL; CP001396; ACR64065.1; -; Genomic_DNA.
DR   RefSeq; YP_002928945.1; NC_012759.1.
DR   ProteinModelPortal; C5A133; -.
DR   STRING; 595496.BWG_3753; -.
DR   EnsemblBacteria; ACR64065; ACR64065; BWG_3753.
DR   GeneID; 7952635; -.
DR   KEGG; ebw:BWG_3753; -.
DR   PATRIC; 18277283; VBIEscCol60876_4103.
DR   eggNOG; COG0382; -.
DR   HOGENOM; HOG000003696; -.
DR   KO; K03179; -.
DR   OMA; AFSWAIP; -.
DR   OrthoDB; EOG680X3B; -.
DR   ProtClustDB; PRK12848; -.
DR   BioCyc; ECOL595496:GI18-3915-MONOMER; -.
DR   UniPathway; UPA00232; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004659; F:prenyltransferase activity; IEA:InterPro.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01635; UbiA; 1.
DR   InterPro; IPR006370; HB_polyprenyl-transferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Magnesium;
KW   Membrane; Transferase; Transmembrane; Transmembrane helix;
KW   Ubiquinone biosynthesis.
FT   CHAIN         1    290       4-hydroxybenzoate octaprenyltransferase.
FT                                /FTId=PRO_1000215802.
FT   TRANSMEM     23     43       Helical; (Potential).
FT   TRANSMEM     46     66       Helical; (Potential).
FT   TRANSMEM     99    119       Helical; (Potential).
FT   TRANSMEM    163    183       Helical; (Potential).
FT   TRANSMEM    213    233       Helical; (Potential).
FT   TRANSMEM    234    254       Helical; (Potential).
FT   TRANSMEM    268    288       Helical; (Potential).
SQ   SEQUENCE   290 AA;  32512 MW;  F10FED1D7A30E115 CRC64;
     MEWSLTQNKL LAFHRLMRTD KPIGALLLLW PTLWALWVAT PGVPQLWILA VFVAGVWLMR
     AAGCVVNDYA DRKFDGHVKR TANRPLPSGA VTEKEARALF VVLVLISFLL VLTLNTMTIL
     LSIAALALAW VYPFMKRYTH LPQVVLGAAF GWSIPMAFAA VSESVPLSCW LMFLANILWA
     VAYDTQYAMV DRDDDVKIGI KSTAILFGQY DKLIIGILQI GVLALMAIIG ELNGLGWGYY
     WSILVAGALF VYQQKLIANR EREACFKAFM NNNYVGLVLF LGLAMSYWHF
//
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