ID UBIA_ECOBW Reviewed; 290 AA.
AC C5A133;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 29-MAY-2013, entry version 29.
DE RecName: Full=4-hydroxybenzoate octaprenyltransferase;
DE EC=2.5.1.-;
DE AltName: Full=4-HB polyprenyltransferase;
GN Name=ubiA; OrderedLocusNames=BWG_3753;
OS Escherichia coli (strain K12 / MC4100 / BW2952).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=595496;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MC4100 / BW2952;
RX PubMed=19376874; DOI=10.1128/JB.00118-09;
RA Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L.,
RA Reeves P.R., Wang L.;
RT "Genomic sequencing reveals regulatory mutations and recombinational
RT events in the widely used MC4100 lineage of Escherichia coli K-12.";
RL J. Bacteriol. 191:4025-4029(2009).
CC -!- FUNCTION: Synthesis of 3-octaprenyl-4-hydroxybenzoate (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: 4-hydroxybenzoate + farnesylfarnesylgeraniol =
CC 3-octaprenyl-4-hydroxybenzoate.
CC -!- COFACTOR: Magnesium (By similarity).
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
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DR EMBL; CP001396; ACR64065.1; -; Genomic_DNA.
DR RefSeq; YP_002928945.1; NC_012759.1.
DR ProteinModelPortal; C5A133; -.
DR STRING; 595496.BWG_3753; -.
DR EnsemblBacteria; ACR64065; ACR64065; BWG_3753.
DR GeneID; 7952635; -.
DR KEGG; ebw:BWG_3753; -.
DR PATRIC; 18277283; VBIEscCol60876_4103.
DR eggNOG; COG0382; -.
DR HOGENOM; HOG000003696; -.
DR KO; K03179; -.
DR OMA; YHYTLIR; -.
DR ProtClustDB; PRK12848; -.
DR BioCyc; ECOL595496:GI18-3915-MONOMER; -.
DR UniPathway; UPA00232; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; IEA:HAMAP.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_01635; UbiA; 1; -.
DR InterPro; IPR006370; HB_polyprenyl-transferase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR PROSITE; PS00943; UBIA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome; Magnesium;
KW Membrane; Transferase; Transmembrane; Transmembrane helix;
KW Ubiquinone biosynthesis.
FT CHAIN 1 290 4-hydroxybenzoate octaprenyltransferase.
FT /FTId=PRO_1000215802.
FT TRANSMEM 23 43 Helical; (Potential).
FT TRANSMEM 46 66 Helical; (Potential).
FT TRANSMEM 99 119 Helical; (Potential).
FT TRANSMEM 163 183 Helical; (Potential).
FT TRANSMEM 213 233 Helical; (Potential).
FT TRANSMEM 234 254 Helical; (Potential).
FT TRANSMEM 268 288 Helical; (Potential).
SQ SEQUENCE 290 AA; 32512 MW; F10FED1D7A30E115 CRC64;
MEWSLTQNKL LAFHRLMRTD KPIGALLLLW PTLWALWVAT PGVPQLWILA VFVAGVWLMR
AAGCVVNDYA DRKFDGHVKR TANRPLPSGA VTEKEARALF VVLVLISFLL VLTLNTMTIL
LSIAALALAW VYPFMKRYTH LPQVVLGAAF GWSIPMAFAA VSESVPLSCW LMFLANILWA
VAYDTQYAMV DRDDDVKIGI KSTAILFGQY DKLIIGILQI GVLALMAIIG ELNGLGWGYY
WSILVAGALF VYQQKLIANR EREACFKAFM NNNYVGLVLF LGLAMSYWHF
//
