ID C5A4H1_THEGJ Unreviewed; 662 AA.
AC C5A4H1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Formate dehydrogenase alpha subunit (FdhA) {ECO:0000313|EMBL:ACS33133.1};
DE EC=1.2.1.2 {ECO:0000313|EMBL:ACS33133.1};
GN Name=fdhA {ECO:0000313|EMBL:ACS33133.1};
GN OrderedLocusNames=TGAM_0631 {ECO:0000313|EMBL:ACS33133.1};
OS Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=593117 {ECO:0000313|EMBL:ACS33133.1, ECO:0000313|Proteomes:UP000001488};
RN [1] {ECO:0000313|EMBL:ACS33133.1, ECO:0000313|Proteomes:UP000001488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15229 / JCM 11827 / EJ3
RC {ECO:0000313|Proteomes:UP000001488};
RX PubMed=19558674; DOI=10.1186/gb-2009-10-6-r70;
RA Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M.,
RA Anthouard V., Forterre P., Wincker P., Confalonieri F.;
RT "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans,
RT the most radioresistant organism known amongst the Archaea.";
RL Genome Biol. 10:R70.1-R70.23(2007).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001398; ACS33133.1; -; Genomic_DNA.
DR RefSeq; WP_015858251.1; NC_012804.1.
DR AlphaFoldDB; C5A4H1; -.
DR STRING; 593117.TGAM_0631; -.
DR PaxDb; 593117-TGAM_0631; -.
DR GeneID; 7987254; -.
DR KEGG; tga:TGAM_0631; -.
DR PATRIC; fig|593117.10.peg.629; -.
DR eggNOG; arCOG01491; Archaea.
DR HOGENOM; CLU_000422_4_0_2; -.
DR OrthoDB; 23466at2157; -.
DR Proteomes; UP000001488; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd00508; MopB_CT_Fdh-Nap-like; 1.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:ACS33133.1}.
FT DOMAIN 1..49
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|SMART:SM00926"
SQ SEQUENCE 662 AA; 74355 MW; 01C0B1B8BB03B013 CRC64;
MKTVVCPFCG FGCRLLVDEK SMRAKPYPGQ PNRGKLCPKG LYSLEFVRSQ GRLKRPLKRV
GSAMVPISWG VAVEEIANKL LEIRELYGPD AVAFLSSSKI SNEENYLLQK IARLFGTNNI
DNCARLCHEA SVHALKLAVG TGAQTNPYED LENFNAVLIW GYNPAETHPV VMNYVLRAKR
RGAKVIVVDV RETRTMAFAD YKLIIKPGTD IVLANAMANV ITGEELYDEE FVRSRTSGFS
EVRMAVMKYT PEYAETVTGI PAETIREVAR AFALAGSGAI MWGMGLTQHV SGVENVLAVI
NLALLLGYIG EKGGLYPMRG QNNVQGAAYM GALSEFLPGY VPLTDERFRK RVASLWGVDD
LPTERGLYLT ELWDAIERSD LKALYIVGEN PAVSEADFTR VRRALRKLDL LVVQDVFMTR
TARYAHYVLP ASAFCEKEGS YMNSERRIQW SHKVCEPYAD SKPDWEILAM LGRALGLPGF
NYTRVEEITV EYFRLFPELE ERSVDELKNG EGIFLPRKRL HTWEFATPDG KARFMAVERI
SPWEEPSEEF PLILTTVRLI NHYNTGEMTL RSPSLVKLMG EPKVMINEKD AKRLGITDGD
WVDIETRRGR IRMRAKVGGV PEGLVAIPFH FKANRITSPA LNKAGTPEFK FSACRVKKMK
AP
//