ID C5AMU6_BURGB Unreviewed; 493 AA.
AC C5AMU6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Class V aminotransferase {ECO:0000313|EMBL:ACR31147.1};
GN OrderedLocusNames=bglu_2g07280 {ECO:0000313|EMBL:ACR31147.1};
OS Burkholderia glumae (strain BGR1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=626418 {ECO:0000313|EMBL:ACR31147.1, ECO:0000313|Proteomes:UP000002187};
RN [1] {ECO:0000313|EMBL:ACR31147.1, ECO:0000313|Proteomes:UP000002187}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGR1 {ECO:0000313|EMBL:ACR31147.1,
RC ECO:0000313|Proteomes:UP000002187};
RX PubMed=19329631; DOI=10.1128/JB.00349-09;
RA Lim J., Lee T.H., Nahm B.H., Choi Y.D., Kim M., Hwang I.;
RT "Complete genome sequence of Burkholderia glumae BGR1.";
RL J. Bacteriol. 191:3758-3759(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-
CC alanine; Xref=Rhea:RHEA:43892, Rhea:RHEA-COMP:14737, Rhea:RHEA-
CC COMP:14739, ChEBI:CHEBI:29917, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972,
CC ChEBI:CHEBI:64428; EC=2.8.1.7;
CC Evidence={ECO:0000256|ARBA:ARBA00001357};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. NifS/IscS subfamily.
CC {ECO:0000256|ARBA:ARBA00006490}.
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DR EMBL; CP001504; ACR31147.1; -; Genomic_DNA.
DR RefSeq; WP_012733541.1; NC_012721.2.
DR AlphaFoldDB; C5AMU6; -.
DR STRING; 626418.bglu_2g07280; -.
DR KEGG; bgl:bglu_2g07280; -.
DR PATRIC; fig|626418.3.peg.967; -.
DR eggNOG; COG1104; Bacteria.
DR HOGENOM; CLU_003433_0_1_4; -.
DR Proteomes; UP000002187; Chromosome 2.
DR GO; GO:0031071; F:cysteine desulfurase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR020578; Aminotrans_V_PyrdxlP_BS.
DR InterPro; IPR005939; BLH_phosphatase-like.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR Pfam; PF00266; Aminotran_5; 1.
DR Pfam; PF04273; BLH_phosphatase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00595; AA_TRANSFER_CLASS_5; 1.
PE 3: Inferred from homology;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Aminotransferase {ECO:0000313|EMBL:ACR31147.1};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000002187};
KW Transferase {ECO:0000313|EMBL:ACR31147.1}.
FT DOMAIN 8..367
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT DOMAIN 387..484
FT /note="Beta-lactamase hydrolase-like protein phosphatase-
FT like"
FT /evidence="ECO:0000259|Pfam:PF04273"
SQ SEQUENCE 493 AA; 51799 MW; 4507CDAD3F106693 CRC64;
MTENNTLHYL DYAATTPVDP RVIESMAACL GADGIFGNPA SNSHRAGRLA RDKVEHARAQ
VAALIGADAD EIVWTSGATE SNNLALKGYA DQAADRRHLV TSRIEHKAVL DTMESLASRG
MPVDYVAPTR DGEIRPEDVA AALRPDTGLV SLMLVNNEIG TLTDVGAIAR LVHDAGALLH
VDAAQALGKT PIDVHALGID LLSMSAHKVY GPKGIGALYV RRGLAGRIAP QMHGGGHESG
LRSGTLATHQ IVGMGHACEL AARELESDTA RITALATRLR DAVLAIGGVE QNARAARRIP
HTLSLTVTAP GFHPFMLDEG LAVSSTSACN SAAGKPSHVL TALGLDAAAA GRTVRISVGR
FTGEDDITFA IDSFRRAIEQ CRATAQSGFA ASHQIQPDDL KAIRGAGFRA VICNRPDGES
ADQPAFAEIA AAARELGLDA RYLPVEAADR IGEAQVDAFG AMLDALPKPV LAYCGSGRRA
GLLWERLALR RTA
//
