ID C5B2W0_METEA Unreviewed; 1360 AA.
AC C5B2W0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:ACS41990.1};
GN OrderedLocusNames=MexAM1_META1p4357 {ECO:0000313|EMBL:ACS41990.1};
OS Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB
OS 9133 / AM1) (Methylobacterium extorquens).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylorubrum.
OX NCBI_TaxID=272630 {ECO:0000313|EMBL:ACS41990.1, ECO:0000313|Proteomes:UP000009081};
RN [1] {ECO:0000313|EMBL:ACS41990.1, ECO:0000313|Proteomes:UP000009081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
RC {ECO:0000313|Proteomes:UP000009081};
RX PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA Lidstrom M.E.;
RT "Methylobacterium genome sequences: a reference blueprint to investigate
RT microbial metabolism of C1 compounds from natural and industrial sources.";
RL PLoS ONE 4:E5584-E5584(2009).
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DR EMBL; CP001510; ACS41990.1; -; Genomic_DNA.
DR RefSeq; WP_004446354.1; NC_012808.1.
DR STRING; 272630.MexAM1_META1p4357; -.
DR KEGG; mea:Mex_1p4357; -.
DR eggNOG; COG0110; Bacteria.
DR eggNOG; COG0663; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_002751_0_0_5; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000009081; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR012728; NRPS_C.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR02353; NRPS_term_dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 3.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009081};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 688..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1135..1158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1170..1195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 545..622
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1360 AA; 144645 MW; 84D54AA20A16CD06 CRC64;
MSGLAEVGRH DEGPGESLGG RAVLRGAARP DLIRRETLAD LFRASAAARP DAPCLIDAAE
PGSGGRRPVL TYAEVDARSD AIAAGLSTRG IGPGDVVGLW MARGTELLIA QIGITKSGAA
WLPFDAEAPA DRVAVCLNDA EAKALLVSEA LRPQAPEGTP ALTTAEVLAA GQGASPPDLD
AAGLGPEHPA YLIYTSGSTG VPKGIVISHV NICHFLRSGN AVYGLSADDV VFQGASVAFD
LSMEEIWVPY LVGACLFVAS PAMMGDVESL PAIIAEAGIT VLDTVPTLLA MIPGDLPSVR
LVLLGGEALP EPLVARWATD RRRLFNTYGP TEATVVATAA EMRPGRPVTI GGPIPNYSVY
VADEALNLLA PGEQGELLIG GPGVAAGYLK RPELTAEKFV ANPYPSDGTD PVLYRSGDAV
SMTPEGDIVF HGRIDDQVKI RGFRVELGEI EARIRAQDGI NQAAVVLRRD DEVDRLVAFL
VPERGADLDR AALRKNLAAQ MPPYMVPGHF EAVETLPRLT SGKVDRKALR IAPLTVAVAD
GEQEAPDNET EAALLAAAKK VFGDGPIGLE ADFFSELGGH SLLAARFVGA VRETPALAGI
TLQDVYNGRT LRVMAASLIE RTGGAGAQTA IRDLSFAPPP LLRRALCGLA QAITLPFVIA
LATAQWLGIF VTYLLLTGGG LGFWGELGVL LLVYIGINAV TATIAIAAKW LILGRTKPGR
YPLWGVYYYR WWLAQRLTPL VHIKWLQGSP VIVTYLRLLG ARIGDDVLIS DLDVGAPDLL
TIGRGASLGG RLVIANAEVV GNELVIGSVE IGEDVAIGTS CVIGPGTVIG DHAEIADLTT
VPAGTEVGPA EAWDGSPGRR VGTVDFAALP EPATASPARR AAFGAVYAFL LAAVPAVGLL
PIFPAFYLFD QISDNLSELT DVDYHVYLPL LTWPTAMLMT AGTVLLIAAI RWAVLPRVTH
GTFSIWSGFY LRKWLVALAS EVTLETLSSL FATVYMRAWY RLMGARMGRG AEISTNLGSR
HDLVAVGANN FIADEVVVGE EEIRRGWMHL HPVETGARVF VGNDGVLPPG AHIPDDVLIG
IKSKPPANDK MGPGETWFGS PPIRLPVRQK VDLGSNAQTF EPSVWAKLRR GLFEAFATSF
SPMLYISLAI CAIDWVFYPA ILAEDWGGLA LAFVLVSLAI ALIQTSSVIA LKWLLMGRYR
PGMRPMWSWW AMRTEAIAVA YWGLAGKVLL EHLMGTPFLP WMLRLFGVKV GKGACLLMTD
ITEFDCVEIG DFAAINRSAA LQTHLYEDRI MKVGRVVVGR GVTVGAFSTV LYDSHVGDYA
RLRPLTIVMK GESIPAHSEW EGAPAVPVVH AAGEAVARAA
//
