ID C5BET8_EDWI9 Unreviewed; 433 AA.
AC C5BET8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Cytosol aminopeptidase family protein, catalytic domain protein {ECO:0000313|EMBL:ACR70326.1};
DE EC=3.4.11.23 {ECO:0000313|EMBL:ACR70326.1};
GN OrderedLocusNames=NT01EI_3176 {ECO:0000313|EMBL:ACR70326.1};
OS Edwardsiella ictaluri (strain 93-146).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Edwardsiella.
OX NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR70326.1, ECO:0000313|Proteomes:UP000001485};
RN [1] {ECO:0000313|Proteomes:UP000001485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACR70326.1, ECO:0000313|Proteomes:UP000001485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-146 {ECO:0000313|EMBL:ACR70326.1,
RC ECO:0000313|Proteomes:UP000001485};
RX PubMed=22247535; DOI=10.1128/JB.06522-11;
RA Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA Lawrence M.L.;
RT "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated with
RT a Natural Channel Catfish Outbreak of Enteric Septicemia of Catfish.";
RL J. Bacteriol. 194:740-741(2012).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR EMBL; CP001600; ACR70326.1; -; Genomic_DNA.
DR RefSeq; WP_015872414.1; NC_012779.2.
DR AlphaFoldDB; C5BET8; -.
DR STRING; 67780.B6E78_07540; -.
DR MEROPS; M17.004; -.
DR KEGG; eic:NT01EI_3176; -.
DR PATRIC; fig|634503.3.peg.2837; -.
DR HOGENOM; CLU_013734_7_1_6; -.
DR OrthoDB; 9809354at2; -.
DR Proteomes; UP000001485; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR047620; M17_PepB-like_N.
DR InterPro; IPR008330; Pept_M17_PepB.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11963:SF20; PEPTIDASE B; 1.
DR Pfam; PF12404; DUF3663; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PIRSF; PIRSF036388; Ctsl_amnpptdse_B; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000313|EMBL:ACR70326.1}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ACR70326.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 276..283
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
SQ SEQUENCE 433 AA; 46604 MW; 8DA7AE022B9C7D23 CRC64;
MTNELMSVHL SSQTADTRWG SDALLSADTQ GMTIHAGESL DHGVIQRAAR RLDTQGMKQV
SLQGTSWSLS ACWAFWQGFR NPKGGQYVQW PALSVADRAE LDRRLLNIDW VRDTINTPAE
NLGPTQLAQR AVDLLCAQAC DSIHYRIIKG DDLREQGYMG LHSVGRGSAR APALLELDYN
PGGKPDTPVL ACLVGKGITF DSGGYSLKQT AFMDSMKSDM GGAALVTGAL ALAIAQGLQA
RVKLYLCCAD NLVSGNAFKL GDIIPYRNGK RVEIMNTDAE GRLVLADGLI DASRQAPRMI
IDCATLTGAA KTAVGGDYHA LLSFDDELVA ALQESADQEE ELFWRLPLAE FHRSQLPSAF
ADLSNVAGVA HSAGASTAAA FLSHFVTDYR QGWLHIDCSA TYRKVAVDQW SAGATGIGVR
TLSRLLLTQA GRC
//
